The Cytotoxic Effectiveness of Thiourea-Reduced Graphene Oxide on Human Lung Cancer Cells and Fungi

Abstract

This study demonstrated the effective reduction of graphene oxide (GO) by employing thiourea as a reducing and stabilizing agent. Two fungi (Aspergillus flavus and Aspergillus fumigatus) were used for anti-fungal assay. Cell viability, cell cycle analysis, DNA fragmentation, and cell morphology were assessed to determine the toxicity of thiourea-reduced graphene oxide (T-rGO) on human lung cancer cells. The results revealed that GO and T-rGO were hazardous to cells in a dose-dependent trend. The viability of both A. fumigatus and A. flavus was affected by GO and T-rGO. The reactive oxygen species produced by T-rGO caused the death of A. flavus and A. fumigatus cells. This study highlighted the effectiveness of T-rGO as an antifungal agent. In addition, T-rGO was found to be more harmful to cancer cells than GO. Thus, T-rGO manifested great potential in biological and biomedical applications.

Evaluation of Antibacterial, Antioxidant, Anti-inflammatory and Anticancer Efficacy of Titanium-Doped Graphene Oxide Nanoparticles

“…Our study of anticancer activity showed 21% for Ti/GO-NPs at 150 µg/mL. Other similar studies showed that lung cancer cells treated with GO showed anticancer activity of 21.69% at 1000 µg/mL [36]. The anticancer activity responds to the lung cancer cells in a dose-dependent manner with cell viability, as the concentration of the nanoparticles increases the cancer cell viability decreases.…”

Visualization of the relationship between fungi and cancer from the perspective of bibliometric analysis

“…Therefore, meticulous efforts have been undertaken to delve into the intricacies of cancer development, diagnosis, and treatment, as the human race strives to overcome this obstinate adversary. As research on the relationship between fungi and cancer continues to deepen, there has been a growing interest in exploring this area [ [5] , [6] , [7] , [108] , [109] , [110] ]. Here, we further analyzed the following aspects related to the research on fungi and cancer.…”

The prevalence of prostate cancer in Pakistan: A systematic review and meta-analysis

“…Cancer is a primary reason of death globally, accounting for over 10 million deaths in 2020, or roughly one in every six deaths [ [1] , [2] , [3] , [4] , [5] ]. Prostate cancer is the most prevalent cancer among men and the second leading cause of cancer mortality after skin cancer [ 6 ].…”