The d-amphetamine-treated Göttingen miniature pig: an animal model for assessing behavioral effects of antipsychotics

Staay, Franz Josef van der; Pouzet, Bruno; Mahieu, Michel; Nordquist, Rebecca E.; Schuurman, T.

doi:10.1007/s00213-009-1599-z

Cited by 17 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent increase in the use of pigs as models in neuroscience, cognition, and neurobehavioral studies is due to the close similarity in brain development, growth and anatomy to humans ( Dickerson and Dobbing, 1966 ; Gieling et al, 2011 ; Glauser, 1966 ; Lind et al, 2007 ; Lunney, 2007 ; Thibault and Margulies, 1998 ). Porcine models for translational research of schizophrenia ( Lind et al, 2005 ; Lind et al, 2004 ), antipsychotic interventions ( van der Staay et al, 2009 ), epilepsy ( Marchi et al, 2007 ), intrauterine growth restriction ( Bauer et al, 2007 , Burke et al, 2006 , Ferenc et al, 2014 , Gonzalez-Bulnes et al, 2016 ), learning ( Andersen et al, 2016 ), and social interactions ( Kanitz et al, 2016 ) have been also developed. Pigs are multiparous animals with the same or larger litters than in mice and the length of gestation in pigs, 114 days, closely approximates gestation in humans.…”

Section: Introductionmentioning

confidence: 99%

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring

et al. 2017

View full text Add to dashboard Cite

Outcomes of Zika virus (ZIKV) infection in pregnant women vary from the birth of asymptomatic offspring to abnormal development and severe brain lesions in fetuses and infants. There are concerns that offspring affected in utero and born without apparent symptoms may develop mental illnesses. Therefore, animal models are important to test interventions against in utero infection and health sequelae in symptomatic and likely more widespread asymptomatic offspring. To partially reproduce in utero infection in humans, we directly inoculated selected porcine conceptuses with ZIKV. Inoculation resulted in rapid trans-fetal infections, persistent infection in conceptuses, molecular pathology in fetal brains, fetal antibody and type I interferon responses. Offspring infected in utero showed ZIKV in their fetal membranes collected after birth. Some in utero affected piglets were small, depressed, had undersized brains, and showed seizures. Some piglets showed potentially increased activity. Our data suggest that porcine model of persistent in utero ZIKV infection has a strong potential for translational research and can be used to test therapeutic interventions in vivo.

show abstract

Section: Introductionmentioning

confidence: 99%

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that the pig is responsive to amphetamine. Pigs have been used to demonstrate amphetamine-induced hyperlocomotion (van der Staay et al 2009) and DA release in response to amphetamine (Lind et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

2012

View full text Add to dashboard Cite

show abstract

“…27,28 Compared with esophageal squamous mucosa, hypopharynx mucosa is easily injured by reflux contents. 29 In the esophagus, upper limit of tolerance to GER is 50 times per day in the normal physiological condition, but in the hypopharynx, upper limit is generally below 7 times per day.…”

Section: Discussionmentioning

confidence: 99%

A Bama Minipig Model of Laryngopharyngeal Reflux and the Change of Laryngopharyngeal Mucosal Ultrastructure

Feng

Zhang²,

Chun-yan

et al. 2015

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/Aims To establish an animal model of laryngopharyngeal reflux (LPR) and study the effect of LPR on the laryngopharyngeal mucosal ultrastructure. Methods Ten Bama minipigs were randomly divided into control group and stent group. Every pig underwent endoscope, and baseline pH was monitored for 4 hours at laryngopharynx and distal esophagus, then specimens from laryngopharyngeal mucosa were biopsied. For the control group, these procedures were repeated on the 14th day. In the stent group, a custom-designed esophageal stent suit was implanted into esophagus, laryngopharyngeal and distal esophageal pH monitoring lasted for 2 hours, then stent suit was removed 3 days later. At last, the same procedures were done as the control group on the 14th day. Specimens were observed under transmission electron microscope to measure the intercellular space and desmosome number. Results In the control group, there was no laryngopharyngeal reflux on the first day and 14th day. Before the stent was implanted, there was also no laryngopharyngeal reflux in the stent group. In both 2 hours and 14 days after stent implantation, the num -ber of reflux, reflux time, and percentage time of pH < 4.0 were significantly increased ( P < 0.05) in the stent group. There was no difference in intercellular space and desmosomes in the control group between baseline and 14th day. In the stent group, intercellular space of laryngopharyngeal mucosa was significantly increased (0.37 μm vs 0.96 μm, P = 0.008), and the number of desmosomes was significantly decreased (20.25 vs 9.5, P = 0.003). Conclusions A Bama minipig model of LPR was established by implanting a custom-designed stent suit. LPR might destroy the laryngophar yngeal mucosal barrier.

show abstract

The d-amphetamine-treated Göttingen miniature pig: an animal model for assessing behavioral effects of antipsychotics

Cited by 17 publications

References 33 publications

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring

Amphetamine challenge decreases yohimbine binding to α2 adrenoceptors in Landrace pig brain

A Bama Minipig Model of Laryngopharyngeal Reflux and the Change of Laryngopharyngeal Mucosal Ultrastructure

Contact Info

Product

Resources

About