The daily intake and serum levels of copper, selenium and zinc are associated with osteoarthritis but not with rheumatoid arthritis in a cross-section study

Yang, Weiming; Wang, Yuan‐Yuan; Xu, Yanmei; Jin, Lin; Liu, Jing; Lv, Jiao-Feng; Chen, Juanjuan; Wang, Xiaozhong

doi:10.21203/rs.3.rs-2418054/v1

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…It promotes regeneration of articular cartilage, enhances chondrogenesis differentiation and regulates cellular and humoral immunity [ 56 ]. However, its role may be considered bidirectional; in OA patients, serum Cu levels are higher compared with healthy controls [ 57 ] and Cu accumulation in Wilson's disease is related to early-onset of OA [ 58 ], probably due to the copper-mediated oxidations and collagen degradation when free Cu occurs in excess [ 59 ]. Contradictory findings have been found in the literature about changes in circulation levels with aging; unaltered levels with aging were seen in patients aged 75 to 85 as well as younger subjects (55 to 64 years) [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Copper Is Associated with Inflammatory Biomarkers in Greek Older Adults with Osteoarthritis

Amerikanou,

Valsamidou,

Karavoltsos

et al. 2023

Biol Trace Elem Res

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Osteoarthritis (OA) is the most common form of arthritis, that causes a significant decrease in the quality of life of the afflicted and constitutes a great burden for the socioeconomic system. Trace elements and heavy metals are implicated in the pathophysiology of OA, exacerbating inflammatory and oxidative stress responses. The aim of this cross-sectional study was to quantify metals in plasma samples of Greek OA patients and explore their link with disease related parameters, health status or quality of life, as well as epigenetic OA markers. This is the first study on plasma metal levels in Greek knee OA patients. To achieve precision in plasma metal and miRNA measurements, high-quality samples were selected from a subset of 34 participants (NCT04783792). Demographic, quality of life, clinical, biochemical, inflammation, oxidative stress, and anthropometric parameters, as well as microRNA levels were assessed. Significant correlations were found between circulating metals with OA related parameters or with measured microRNAs. Also, significant positive associations between plasma copper (Cu) levels and CRP (p = 0.033) or IL-6 (p = 0.001) occurred when adjusting for age, gender, BMI, physical activity level, smoking, disease severity, total arthroplasty, and dietary intake of the respective metal. Cu’s role in OA is bidirectional, and this study confirms the findings that in OA, Cu is positively associated with inflammation. Such relationships between lifestyle, environment and OA enhance our understanding and encourage further study on metals related to OA inflammation.

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Section: Discussionmentioning

confidence: 99%

Circulating Copper Is Associated with Inflammatory Biomarkers in Greek Older Adults with Osteoarthritis

Amerikanou,

Valsamidou,

Karavoltsos

et al. 2023

Biol Trace Elem Res

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Identification of key genes and immune infiltration in osteoarthritis through analysis of zinc metabolism-related genes

You,

Ye,

Lin

et al. 2024

BMC Musculoskelet Disord

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Background Osteoarthritis (OA) represents a prominent etiology of considerable pain and disability, and conventional imaging methods lack sensitivity in diagnosing certain types of OA. Therefore, there is a need to identify highly sensitive and efficient biomarkers for OA diagnosis. Zinc ions feature in the pathogenesis of OA. This work aimed to investugate the role of zinc metabolism-related genes (ZMRGs) in OA and the diagnostic characteristics of key genes. Methods We obtained datasets GSE169077 and GSE55235 from the Gene Expression Omnibus (GEO) and obtained ZMRGs from MSigDB. Differential expression analysis was conducted on the GSE169077 dataset using the limma R package to identify differentially expressed genes (DEGs), and the intersection of DEGs and ZMRGs yielded zinc metabolism differential expression-related genes (ZMRGs-DEGs). The clusterProfiler R package was employed for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of ZMRGs-DEGs. Potential small molecule drugs were predicted using the CMap database, and immune cell infiltration and function in OA individuals were analyzed using the ssGSEA method. Protein-protein interaction (PPI) networks were constructed to detect Hub genes among ZMRGs-DEGs. Hub gene expression levels were analyzed in the GSE169077 and GSE55235 datasets, and their diagnostic characteristics were assessed using receiver operating characteristic (ROC) curves. The gene-miRNA interaction network of Hub genes was explored using the gene-miRNA interaction network website. Results We identified 842 DEGs in the GSE169077 dataset, and their intersection with ZMRGs resulted in 46 ZMRGs-DEGs. ZMRGs-DEGs were primarily enriched in functions such as collagen catabolic processes, extracellular matrix organization, metallopeptidase activity, and pathways like the IL-17 signaling pathway, Nitrogen metabolism, and Relaxin signaling pathway. Ten potential small-molecule drugs were predicted using the CMap database. OA patients exhibited distinct immune cell abundance and function compared to healthy individuals. We identified 4 Hub genes (MMP2, MMP3, MMP9, MMP13) through the PPI network, which were highly expressed in OA and demonstrated good diagnostic performance. Furthermore, two closely related miRNAs for each of the 4 Hub genes were identified. Conclusion 4 Hub genes were identified as potential diagnostic biomarkers and therapeutic targets for OA.

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The daily intake and serum levels of copper, selenium and zinc are associated with osteoarthritis but not with rheumatoid arthritis in a cross-section study

Cited by 2 publications

References 32 publications

Circulating Copper Is Associated with Inflammatory Biomarkers in Greek Older Adults with Osteoarthritis

Circulating Copper Is Associated with Inflammatory Biomarkers in Greek Older Adults with Osteoarthritis

Identification of key genes and immune infiltration in osteoarthritis through analysis of zinc metabolism-related genes

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