Using a simplified framework, we attempt to explain the recent DAMPE cosmic e + + e − flux excess by leptophilic Dirac fermion dark matter (LDM). The scalar (Φ 0 ) and vector (Φ 1 ) mediator fields connecting LDM and Standard Model particles are discussed. We find that the couplings P ⊗ S, P ⊗ P , V ⊗ A and V ⊗ V can produce the right bump in e + + e − flux for a DM mass around 1.5 TeV with a natural thermal annihilation crosssection < σv >∼ 3×10 −26 cm 3 /s today. Among them, V ⊗V coupling is tightly constrained by PandaX-II data (although LDM-nucleus scattering appears at one-loop level) and the surviving samples appear in the resonant region, m Φ 1 2m χ . We also study the related collider signatures, such as dilepton production pp → Φ 1 → + − , and muon g −2 anomaly. Finally, we present a possible U(1) X realization for such leptophilic dark matter.