The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy

Delago, Daniela; Knittelfelder, Olivia; Jakse, G; Łukasiak, Katarzyna; Reinisch, Sabine; Renner, Wilfried; Stranzl-Lawatsch, Heidi; Partl, Richard; Langsenlehner, Tanja

doi:10.1186/s13014-020-01702-4

Cited by 12 publications

(9 citation statements)

References 35 publications

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“…Recent studies showed that RDW was significantly higher in DTC and PTC patients than in the control group (16,29). In another study, when the postoperative results of patients who underwent thyroidectomy due to atypia/follicular lesion of undetermined significance were divided as benign and malignant, preoperative RDW was found to be higher in the malignant group than in the benign group (30). In our study, higher RDW was found in all groups compared to the control group.…”

Section: Discussionsupporting

confidence: 51%

Evaluation of Inflammation-Related Hemogram Parameters as a Useful Marker in Papillary Thyroid Carcinoma

Sözen

CANTÜRK

Selek

et al. 2022

SDÜ Tıp Fakültesi Dergisi

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Objectives: Inflammation-related hemogram parameters have recently started to be defined as a useful marker in cancer patients. In this study, we aimed to comparison of hemogram parameters in papillary thyroid cancer (PTC) patients, well differentiated thyroid tumor of uncertain malignant potential (WDT-UMP) and follicular adenoma (FA). Materials and Methods: The 287 patients data were analyzed in study. Study subjects were divided into 5 different groups. 1st group: control, 2nd group: FA, 3rd group: WDT-UMP, 4th group: non-metastatic PTC, 5th group: metastatic PTC. We evaluated the preoperative blood tests. Results: The average age was 50 (37-59). The mean TSH value was 1.2 (0.5-2.2) µIU/mL. The mean size of the lesion detected in the total thyroidectomy material was 1.7 (1.0-3.0) cm. White blood cells (WBC), neutrophils and lymphocytes were lower in 3rd group than 4th group (p0.173). MPV was found to be statistically higher in the control patients (p=0.000). MPV was significantly higher in 2nd group compared to 3rd group and 4th group (p=0.001, p=0.016; respectively). RDW was significantly lower in the control group compared to all other groups (p=0.000). There was no correlation between tumor size and hemogram parameters. Conclusions: In patients followed up for thyroid nodules, low MPV should raise a suspicion in terms of possible malignancy. Increased RDW may be useful in predicting thyroid nodule development. These easily accessible, cost-effective markers may support other diagnostic methods to distinguish malignant from benign nodules.

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Section: Discussionsupporting

confidence: 51%

Evaluation of Inflammation-Related Hemogram Parameters as a Useful Marker in Papillary Thyroid Carcinoma

Sözen

CANTÜRK

Selek

et al. 2022

SDÜ Tıp Fakültesi Dergisi

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“…32 Moreover, platelets can get activated on encountering circulating tumor cells which result in the formation of microparticles that can potentially promote the invasiveness of tumor cells. 33 Therefore, this close interplay between high MPV and poor prognosis of cancers can be a reasonable hypothesis. In contrast, our ndings do not support the hypothesis that an MPV level is a prognostic factor for poor outcomes in lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of mean platelet volume in lung cancer patients: A meta-analysis

Kharel

Shrestha

Shakya

et al. 2021

Preprint

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Background Lung cancer is the most prevalent cancer globally with a grim prognosis alongside a very high number of cancer-related deaths. Mean platelet volume (MPV) is the measure of platelet size and is considered a surrogate marker of platelet activation. Low MPV indicates exhausted platelets causing worse outcomes in cancer patients. As the correlation between platelet count/platelet size and lung cancer prognosis still remains a topic of debate, this meta-analysis was done to comprehensively evaluate the prognostic significance of MPV among lung cancer patients.Methods A systematic search of electronic databases PubMed, Embase, and Google scholar and additional sources for relevant studies were done with no language restrictions from inception to 7th May 2021. Overall Survival (OS) and Disease-Free Survival (DFS)/Progression-Free Survival (PFS) and hazard ratio (HR) with 95% Confidence Interval (CI) were pooled to evaluate the relation of MPV with OS/DFS. Subgroup analysis based on cancer type, clinical stage, sample size, median age, cut-off value, and study region was done to identify the cause of significant heterogeneity.Results Eleven studies with 2421 lung cancer patients were included in our analysis. Our analysis showed no significant association between MPV levels with OS (H.R.:1.07, 95%C.I.:0.84–1.35, p = 0.60) and DFS/PFS (HR:1.04, 95%C.I.:0.68–1.60, p = 0.84). Under subgroup analysis, studies conducted in countries other than China (HR:1.53, 95% C.I.=1.14–2.03, p < 0.001, I2 = 42.11%) and studies with advanced-stage lung cancer patients (HR: 1.84, 95% C.I.=1.19–2.82, p-value = 0.01, I2 = 0%) showed significant association between MPV levels and worse DFS/PFS.Conclusion Pretreatment MPV levels did not show prognostic significance except in advanced lung cancer cases. Large multicentric studies with large samples and long follow-up times are necessary.

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“…32 Moreover, platelets can be activated upon encountering circulating tumor cells, which results in the formation of microparticles that can potentially promote the invasiveness of tumor cells. 33 Therefore, this close interplay between high MPV and poor prognosis in cancer is a reasonable hypothesis. By contrast, our findings do not support the hypothesis that MPV is a prognostic factor for poor outcomes in patients with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis

et al. 2022

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Objective The mean platelet volume (MPV) is a measure of platelet size, and it is considered a surrogate marker of platelet activation. Because the correlation between platelet count/size and lung cancer prognosis remains unclear, this meta-analysis comprehensively evaluated the prognostic significance of MPV among patients with lung cancer. Methods A systematic search of PubMed, Embase, Google Scholar, and additional sources of relevant studies were conducted with no language restrictions from inception to 7 May 2021. Overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS), as well as their hazard ratios (HR) and 95% confidence intervals (CIs), were pooled to evaluate the relationship between MPV and survival. The study protocol was registered on PROSPERO. Results Eleven studies involving 2421 patients with lung cancer were included in our analysis. Nine studies including only patients with non-small cell lung cancer were included in the meta-analysis. Our analysis revealed no significant associations of MPV with OS (HR = 1.09, 95% CI = 0.84–1.41) and DFS/PFS (HR = 1.13, 95% CI = 0.58–2.20). Conclusion Pretreatment MPV levels did not display prognostic significance in patients with NSCLC. Large-scale prospective studies and a validation study considering ethnicity and lung cancer staging are warranted.

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The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy

Cited by 12 publications

References 35 publications

Evaluation of Inflammation-Related Hemogram Parameters as a Useful Marker in Papillary Thyroid Carcinoma

Evaluation of Inflammation-Related Hemogram Parameters as a Useful Marker in Papillary Thyroid Carcinoma

Prognostic significance of mean platelet volume in lung cancer patients: A meta-analysis

Prognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis

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