The degradation of the three layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane in vitro

Liao, Susan; Watari, Fumio; Zhu, Yuhe; Uo, Motohiro; Akasaka, Tsukasa; Wang, Wei; Xu, Gaohong; Cui, Fuzhai

doi:10.1016/j.dental.2006.06.045

Cited by 97 publications

(58 citation statements)

References 35 publications

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“…Another approach comprises precipitation of nanodimensional apatites from aqueous solutions in the presence of dissolved high molecular weight polyacrylic acid [488,489] that acts as an inhibitor for the crystallization of apatite crystals [490,491]. A similar inhibiting effect was found for dimethyl acetamide [492], polyvinyl alcohol [291] and several other (bio)polymers [493,494]. This type of synthesis is expected to lead to formation of nanodimensional composites, which might be structurally more comparable to bones with closely related mechanical and biological properties.…”

Section: Yearmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: Yearmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Meanwhile, it is well known that natural bone is composed of collagen and nanoapatite crystallites of approximately 50 nm (Watari 2001(Watari , 2005. When the nanocomposites of apatite and collagen fibrils were biomimetically synthesized (Liao et al 2005(Liao et al , 2007aGelinsky et al 2007;Li et al 2008a,d ) and implanted in subcutaneous tissue, they were covered with fibrous connective tissue and then mostly resorbed in eight weeks by phagocytosis . Therefore, nanoapatite composites are bioresorbable.…”

Section: Change From Non-resorbable To Resorbable Apatite By Nanosizingmentioning

confidence: 99%

“…Thus, there exist apatites with different behaviour, non-resorbable and resorbable apatite . It is necessary to know the effect of nanosizing on this change of biofunctions using nanoapatite composites (Liao et al 2005(Liao et al , 2007aGelinsky et al 2007;Li et al 2008a). …”

Section: Nanoapatitementioning

confidence: 99%

Material nanosizing effect on living organisms: non-specific, biointeractive, physical size effects

Watari

Takashi

Yokoyama

et al. 2009

J. R. Soc. Interface.

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100

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Nanosizing effects of materials on biological organisms was investigated by biochemical cell functional tests, cell proliferation and animal implantation testing. The increase in specific surface area causes the enhancement of ionic dissolution and serious toxicity for soluble, stimulative materials. This effect originates solely from materials and enhances the same functions as those in a macroscopic size as a catalyst. There are other effects that become prominent, especially for non-soluble, biocompatible materials such as Ti. Particle size dependence showed the critical size for the transition of behaviour is at approximately 100 mm, 10 mm and 200 nm. This effect has its origin in the biological interaction process between both particles and cells/tissue. Expression of superoxide anions, cytokines tumour necrosis factor-a and interleukin-1b from neutrophils was increased with the decrease in particle size and especially pronounced below 10 mm, inducing phagocytosis to cells and inflammation of tissue, although inductively coupled plasma chemical analysis showed no dissolution from Ti particles. Below 200 nm, stimulus decreases, then particles invade into the internal body through the respiratory or digestive systems and diffuse inside the body. Although macroscopic hydroxyapatite, which exhibits excellent osteoconductivity, is not replaced with natural bone, nanoapatite composites induce both phagocytosis of composites by osteoclasts and new bone formation by osteoblasts when implanted in bone defects. The progress of this bioreaction results in the conversion of functions to bone substitution. Although macroscopic graphite is non-cell adhesive, carbon nanotubes (CNTs) are cell adhesive. The adsorption of proteins and nano-meshwork structure contribute to the excellent cell adhesion and growth on CNTs. Non-actuation of the immune system except for a few innate immunity processes gives the non-specific nature to the particle bioreaction and restricts reaction to the size-sensitive phagocytosis. Materials larger than cell size, approximately 10 mm, behave inertly, but those smaller become biointeractive and induce the intrinsic functions of living organisms. This bioreaction process causes the conversion of functions such as from biocompatibility to stimulus in Ti-abraded particles, from non-bone substitutional to bone substitutional in nanoapatite and from non-cell adhesive to cell adhesive CNTs. The insensitive nature permits nanoparticles that are less than 200 nm to slip through body defence systems and invade directly into the internal body.

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“…PCL can last within the body for more than 2 years [130]. The synthetic polymer, PLGA (85:15) usually degrades within 26 weeks, but PLGA (50:50) will degrade between 6 and 8 weeks in vitro [131][132][133]. Silk scaffolds, however, can be modified to have similar degradation rates by changing the solvent for electrospinning [128].…”

Section: Electrospinning Silk Fibroinmentioning

confidence: 99%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

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Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo, due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.

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The degradation of the three layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane in vitro

Cited by 97 publications

References 35 publications

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Material nanosizing effect on living organisms: non-specific, biointeractive, physical size effects

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

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