The Degree Of Dysplasia in Neutrophils With a Special Note On Pelger- Huët Anomaly.

Abstract

The Pelger-Huët anomaly (PHA), an autosomal dominant condition ,is characterized by morphologically abnormal neutrophil. This article summarizes the history of PHA , pathogenesis and guidance for differentiating congenital or acquired PHA, with their different morphological variants. We report an interesting case of pseudo-PHA in a 70 year old male diagnosed with Leptospirosis, showing unilobed, unilobed intended, bilobed pelgeroid cells in the peripheral smear.

Inherited Disorder: Pelger-Huët Anomaly

“…3 Only three years later, Huët, who was also a Dutch, pronounced it as an inherited disorder. 4 In fact, Huët was pediatrician and he recognized the "Pelger anomaly" in a 7-year-old girl with tuberculosis who recovered from her illness. 3 Moreover, while examining smears of peripheral blood showed the Pelger anomaly in several of the child's relatives.…”