The delayed degradation mechanism and mechanical properties of β-TCP filler in poly(lactide-<i>co</i>-glycolide)/beta-tricalcium phosphate composite suture anchors during short-time degradation in vivo

Luo, Youran; Zhang, Li; Chen, Cheng; Sun, Dong-Yuan; Wu, Pingbo; Wang, Yue; Liao, Yunmao; Cao, Xia; Cheng, Cheng‐Kung; Tang, Ziqing; Lü, Xing

doi:10.1557/jmr.2018.407

Cited by 6 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4(a) , the PLGA diffraction peak was located at 2θ = 10–26.47°. 26 The relevant MBG diffraction peaks at 2θ = 15°–35° were identifiable in PLGA–MBG and PLGA–MBG–Sim composites. 27 In PLGA–MBG–Sim composites [ Fig.…”

Section: Resultsmentioning

confidence: 95%

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering

Murugan,

Dalavi,

Surya

et al. 2023

APL Bioengineering

View full text Add to dashboard Cite

Due to the limitations of the current treatment approaches of allograft and autograft techniques, treating bone disorders is a significant challenge. To address these shortcomings, a novel biomaterial composite is required. This study presents the preparation and fabrication of a novel biomaterial composite scaffold that combines poly (D, L-lactide-co-glycolide) (PLGA), mesoporous bioactive glass (MBG), molybdenum disulfide (MoS2), and simvastatin (Sim) to address the limitations of current bone grafting techniques of autograft and allograft. The fabricated scaffold of PLGA–MBG–MoS2–Sim composites was developed using a low-cost hydraulic press and salt leaching method, and scanning electron microscopy (SEM) analysis confirmed the scaffolds have a pore size between 143 and 240 μm. The protein adsorption for fabricated scaffolds was increased at 24 h. The water adsorption and retention studies showed significant results on the PLGA–MBG–MoS2–Sim composite scaffold. The biodegradation studies of the PLGA–MBG–MoS2–Sim composite scaffold have shown 54% after 28 days. In vitro, bioactivity evaluation utilizing simulated body fluid studies confirmed the development of bone mineral hydroxyapatite on the scaffolds, which was characterized using x-ray diffraction, Fourier transform infrared, and SEM analysis. Furthermore, the PLGA–MBG–MoS2–Sim composite scaffold is biocompatible with C3H10T1/2 cells and expresses more alkaline phosphatase and mineralization activity. Additionally, in vivo research showed that PLGA–MBG–MoS2–Sim stimulates a higher rate of bone regeneration. These findings highlight the fabricated PLGA–MBG–MoS2–Sim composite scaffold presents a promising solution for the limitations of current bone grafting techniques.

show abstract

Section: Resultsmentioning

confidence: 95%

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering

Murugan,

Dalavi,

Surya

et al. 2023

APL Bioengineering

View full text Add to dashboard Cite

show abstract

“…Some of the vital factors to be considered are morphology, aperture, porosity, and spatial orientation. The right amount of pore size is advantageous toward promoting cell attachment, migration, proliferation, differentiation, and finally bone regeneration [ 52 ]. Technical issues can affect biomaterial functionality [ 32 ] and can potentially alter the microenvironment relative to the scaffold, thereby causing cell infiltration.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of Bone Regenerative Capacity of the Novel Nanobiomaterial: β-Tricalcium Phosphate Polylactic Acid-co-Glycolide (β-TCP/PLLA/PGA) for Use in Maxillofacial Bone Defects

Ramanathan,

Shijirbold,

Okui

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

Maxillofacial bone defects are treated by autografting or filling with synthetic materials in various forms and shapes. Electrospun nanobiomaterials are becoming popular due to their easy placement and handling; combining ideal biomaterials extrapolates better outcomes. We used a novel electrospun cotton-like fiber made from two time-tested bioresorbable materials, β-TCP and PLLA/PGA, to check the feasibility of its application to maxillofacial bone defects through an in vivo rat mandibular bone defect model. Novel β-TCP/PLLA/PGA and pure β-TCP blocks were evaluated for new bone regeneration through assessment of bone volume, inner defect diameter reduction, and bone mineral density. Bioactive/osteoconductivity was checked by scoring the levels of Runt-related transcription factor x, Leptin Receptor, Osteocalcin, and Periostin biomarkers. Bone regeneration in both β-TCP/PLLA/PGA and β-TCP was comparable at initial timepoints. Osteogenic cell accumulation was greater in β-TCP/PLLA/PGA than in β-TCP at initial as well as late phases. Periostin expression was more marked in β-TCP/PLLA/PGA. This study demonstrated comparable results between β-TCP/PLLA/PGA and β-TCP in terms of bone regeneration and bioactivity, even with a small material volume of β-TCP/PLLA/PGA and a decreased percentage of β-TCP. Electrospun β-TCP/PLLA/PGA is an ideal nanobiomaterial for inducing bone regeneration through osteoconductivity and bioresorbability in bony defects of the maxillofacial region.

show abstract

“…Numerous studies have shown that PLGA has many advantages along with some disadvantages. The toughness of pure PLGA is poor, the mechanical strength of it cannot meet the requirements of loadbearing site applications, the poor cell attachment ability and bioactivity [18], and the degradation products are acidic, which is not conducive to the formation of new bone [19,20].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the nano-hydroxyapatite with different surface modifications on the properties of poly(lactide-co-glycolide acid)/poly(trimethylene carbonate)/nano-hydroxyapatite composites

Xiao

Wang

et al. 2020

Colloid Polym Sci

View full text Add to dashboard Cite

Nano-hydroxyapatite (HA) was successfully treated by three different surface modification methods of oleic acid (OA), silane coupling agent γ-aminopropyl triethoxysilane (KH550), and ethenyltrimethoxysilane (YDH171), respectively. Then, the treated HA and unmodified HA with 8 wt% were introduced into PLGA/PTMC blends, respectively. And the fracture morphology, thermal property, crystallization behavior, mechanical properties, surface wettability, and in vitro bioactivity of PLGA/PTMC/ HA ternary composites were investigated. The results showed that the PLGA/PTMC/HA composite with the HA surface modified by OA had the highest mechanical properties, while the PLGA/PTMC/HA composite with the HA treated by silane coupling agent YDH171 had the excellent toughness, compared to the other samples. Moreover, the cells' proliferation results confirmed that the ternary composites exhibited better biocompatibility. All the results suggested that the surface modification of HA was an ideal method in this study, and they would be potential to be used in the field of bone repair in the future.

show abstract

The delayed degradation mechanism and mechanical properties of β-TCP filler in poly(lactide-co-glycolide)/beta-tricalcium phosphate composite suture anchors during short-time degradation in vivo

Abstract: Abstract

Cited by 6 publications

References 30 publications

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering

In Vivo Evaluation of Bone Regenerative Capacity of the Novel Nanobiomaterial: β-Tricalcium Phosphate Polylactic Acid-co-Glycolide (β-TCP/PLLA/PGA) for Use in Maxillofacial Bone Defects

Investigation of the nano-hydroxyapatite with different surface modifications on the properties of poly(lactide-co-glycolide acid)/poly(trimethylene carbonate)/nano-hydroxyapatite composites

Contact Info

Product

Resources

About