The deleterious toxic effects of bifenthrin on male fertility

Bae, Jeong-Won; Kwon, Woo-Sung

doi:10.1016/j.reprotox.2021.03.002

Cited by 14 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanisms underlying the male reproductive toxicity of pyrethroids are still being explored. One research demonstrated that bifenthrin reduced sperm motility and kinematic parameters by reducing intracellular ATP level ( 68 ). Long term exposure to pyrethroid interferes with the expression of genes that govern spermatogenesis, steroidogenesis, apoptosis, and genetic reprogramming of male gametes ( 69 ).…”

Section: Discussionmentioning

confidence: 99%

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Zhang

Ren

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

Pyrethroids may be related to male reproductive system damage. However, the results of many previous studies are contradictory and uncertain. Therefore, a systematic review and a meta-analysis were performed to assess the relationship between pyrethroid exposure and male reproductive system damage. A total of 72 articles were identified, among which 57 were selected for meta-analysis, and 15 were selected for qualitative analysis. Pyrethroid exposure affected sperm count (SMD= -2.0424; 95% CI, -2.4699 to -1.6149), sperm motility (SMD=-3.606; 95% CI, -4.5172 to -2.6948), sperm morphology (SMD=2.686; 95% CI, 1.9744 to 3.3976), testis weight (SMD=-1.1591; 95% CI, -1.6145 to -0.7038), epididymal weight (SMD=-1.1576; 95% CI, -1.7455 to -0.5697), and serum testosterone level (SMD=-1.9194; 95% CI, -2.4589 to -1.3798) in the studies of rats. We found that gestational and lactational exposure to pyrethroids can reduce sperm count (SMD=1.8469; 95% CI, -2.9010 to -0.7927), sperm motility (SMD=-2.7151; 95% CI, -3.9574 to -1.4728), testis weight (SMD=-1.4361; 95% CI, -1.8873 to -0.9848), and epididymal weight (SMD=-0.6639; 95% CI, -0.9544 to -0.3733) of F1 offspring. Exposure to pyrethroids can increase malondialdehyde (SMD=3.3451; 95% CI 1.9914 to 4.6988) oxide in testes and can reduce the activities of glutathione (SMD=-2.075; 95% CI -3.0651 to -1.0848), superoxide dismutase (SMD=-2.4856; 95% CI -3.9612 to -1.0100), and catalase (SMD=-2.7564; 95% CI -3.9788 to -1.5340). Pyrethroid exposure and oxidative stress could damage male sperm quality. Gestational and lactational pyrethroid exposure affects the reproductive system of F1 offspring.

show abstract

Section: Discussionmentioning

confidence: 99%

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Zhang

Ren

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Spermatozoa were released from the cauda epididymis into BM containing 0.4% BSA. Then, the spermatozoa were incubated with various concentrations of novarulon at 37 °C and 5% CO 2 for 90 min to induce capacitation as described previously [ 11 , 12 , 13 , 14 , 15 ]. The concentrations of novarulon were considered by referring to previous studies [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…The dual staining method (combined Hoechst 33258/chlortetracycline fluorescence assessment) was used to evaluate capacitation status [ 11 , 12 , 13 , 14 , 15 ]. Samples were incubated for 90 min and then centrifuged at 100× g for 2.5 min.…”

Section: Methodsmentioning

confidence: 99%

“…For successful fertilization, ejaculated sperm cells must undergo a special process within the female reproductive tract to acquire the full capacity to fertility, which has been termed “capacitation” [ 9 , 10 ]. In this process, sperm motility patterns change, and the sperm undergoes alterations in various molecular functions, such as protein kinase A activation and tyrosine phosphorylation [ 11 , 12 , 13 , 14 , 15 , 16 ]. Finally, the capacitated sperm cells undergo an acrosomal change, i.e., the acrosome reaction, after which, the acrosome-reacted sperm cell can penetrate the oocyte [ 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…In this process, sperm motility patterns change, and the sperm undergoes alterations in various molecular functions, such as protein kinase A activation and tyrosine phosphorylation [ 11 , 12 , 13 , 14 , 15 , 16 ]. Finally, the capacitated sperm cells undergo an acrosomal change, i.e., the acrosome reaction, after which, the acrosome-reacted sperm cell can penetrate the oocyte [ 11 , 12 , 13 , 14 , 15 , 16 ]. Therefore, the present study was conducted to evaluate the male reproductive toxicity of novaluron by exploring the sperm functions after inducing capacitation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novaluron Has Detrimental Effects on Sperm Functions

Hwang

Bae

Jung

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Although novaluron is an insect growth regulator with a low mammalian acute toxicity and a low risk to the environment and nontarget organisms, toxic effects of novaluron have been reported. However, no studies have yet evaluated the effect of novaluron on reproduction. Therefore, we examined the effects of novaluron on sperm functions. The spermatozoa of ICR mice were incubated with various concentrations of novaluron to induce capacitation. Then, sperm motion parameters and capacitation status were evaluated using CASA program and H33258/chlortetracycline staining. In addition, PKA activity and tyrosine phosphorylation were evaluated by Western blotting. After exposure, various sperm motion parameters were significantly decreased in a dose-dependent manner. The acrosome reaction was also significantly decreased in the high concentration groups. Sperm viability was significantly reduced at the highest concentration. In addition, PKA activity and tyrosine phosphorylation were also significantly altered. Thus, novaluron affects sperm viability, sperm motility, and motion kinematics during capacitation. Furthermore, it may promote the reduction in acrosome reactions. The physiological suppression of sperm function may depend on abnormal tyrosine phosphorylation via the alteration of PKA activity. Therefore, we suggest that it is necessary to consider reproductive toxicity when using novaluron as a pesticide.

show abstract