The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behçet's disease

Wang, L. M.; Kitteringham, Neil R.; Mineshita, Satoru; Wang, J. Z.; Nomura, Yuki; Koike, Yuichi; Miyashita, Eiko

doi:10.1007/s004030050219

Cited by 40 publications

(46 citation statements)

References 6 publications

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“…Various investigations on BD have reported the increased serum IL-8 [2,14,22,29] and spontaneous production of IL-8 by peripheral mononuclear cells [18,30] in BD. One recent report even suggested that serum IL-8 can be a more reliable marker of the disease activity, according to the number of actively involved organs, than C-reactive protein (CRP) or erythrocyte sedimentation rates (ESR) in BD [14].…”

Section: Introductionmentioning

confidence: 99%

Plasma and whole-blood chemokine levels in patients with Behcet's disease

Kaburaki

Fujino

Kawashima

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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Section: Introductionmentioning

confidence: 99%

Plasma and whole-blood chemokine levels in patients with Behcet's disease

Kaburaki

Fujino

Kawashima

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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“…In addition, no laboratory marker has been widely accepted for following up the activity of the disease in clinical and therapeutic studies. Interleukin-8 (IL-8) has recently been under focused investigation because of its possible participation in the evolution of the disorder [4, 5, 6, 7, 8, 9]. Although IL-8 is not a specific marker for Adamantiades-Behçet’s disease, cumulative evidence suggests a significant correlation between disease activity and increased serum levels of IL-8 [4, 9].…”

Section: Introductionmentioning

confidence: 99%

Adamantiades-Behçet’s Disease: Serum IL-8 Is a More Reliable Marker for Disease Activity than C-Reactive Protein and Erythrocyte Sedimentation Rate

et al. 2000

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Background: Interleukin 8 (IL-8) has recently been under focused investigation because of its possible participation in the evolution of Adamantiades-Behçet’s disease. Objective: The reliability of IL-8 as a serological marker for the activity of the disease was investigated in a prospective consecutive trial of 34 cases. Methods: The activity of the disease was clinically evaluated by the number of actively involved organ systems registered on the day of blood sampling and by the presence of oral aphthous ulcers. Serum IL-8 levels were compared to C-reactive protein (CRP) values and the erythrocyte sedimentation rate. Results: An association of IL-8 levels with the activity of the disease was detected when compared with both the number of active clinical signs (p = 0.024) and the presence of oral aphthous ulcers (p = 0.002). In contrast, no association of CRP and sedimentation rate with the activity of the disease could be detected. A weak correlation of IL-8 levels with sedimentation rate values at 2 h was found (R = 0.37, p = 0.032). Conclusion: Our results confirm previous data concerning the significance of IL-8 and, in addition, they provide first evidence for the reliability of IL-8 as a serological marker for assessment of the activity of Adamantiades-Behçet’s disease in the follow-up of clinical and therapeutic studies.

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“…In the previous studies, different SOD levels have been reported for BD patients [25,26]. Wang et al [25] reported increased SOD activity in the active phase of BD, whereas other researchers found decreases [26]. Kiraz et al [24] reported that plasma SOD activities of BD patients were not different from those of controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Serum Nitric Oxide, Malondialdehyde Levels, and Antioxidant Enzyme Activities in Behçet’s Disease with and without Ocular Disease

et al. 2004

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Objective: The pathogenesis of Behçet’s disease (BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/antioxidant system and nitric oxide (NO) and malondialdehyde (MDA) levels in patients with BD and its subtypes: complete Behçet’s disease (CBD) and incomplete Behçet’s disease (ICBD), with or without ocular disease. Methods: Thirty-two patients and 26 age- and sex-matched healthy control subjects were evaluated for NO and MDA levels and antioxidant enzyme activities. The patients with BD were divided into two subgroups: those with and without ocular disease. Twelve patients with CBD and 4 patients with ICBD had ocular disease. The serum NO level was determined by Griess reaction. The MDA level was detected by thiobarbituric acid reaction. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in serum were analyzed with spectrophotometric methods. Results: Increased MDA levels but decreased GSH-Px activities in plasma were observed in BD patients with all subtypes, as compared with controls. Concerning the presence of ocular disease and the subtype (CBD or ICBD) compared with each other, there were no significant differences in MDA or NO serum levels and SOD or GSH-Px enzyme activities. Conclusions: Serum NO levels and SOD enzyme activities were not significantly changed in patients with BD and its subtypes; however, a remarkable decrease of GSH-Px enzyme activity and increase of MDA levels were found.

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The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behçet's disease

Cited by 40 publications

References 6 publications

Plasma and whole-blood chemokine levels in patients with Behcet's disease

Plasma and whole-blood chemokine levels in patients with Behcet's disease

Adamantiades-Behçet’s Disease: Serum IL-8 Is a More Reliable Marker for Disease Activity than C-Reactive Protein and Erythrocyte Sedimentation Rate

Comparison of Serum Nitric Oxide, Malondialdehyde Levels, and Antioxidant Enzyme Activities in Behçet’s Disease with and without Ocular Disease

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