The demonstration of serum interleukin 6–8, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Behçet’s disease with ocular involvement

Abstract

IgA-, C3-, C4-, IL6-, IL8-, and TNF-alpha-mediated mechanisms might be responsible for ocular lesions in BD.

Serum Interleukin-6 and Adiponectin Levels in Patients with Active or Inactive Behçet’s Disease

“…19 Sayi nalp et al simiarly fo und that se rum le vels of IL-1 be ta, IL-2 and IL-6 in the pa ti ents with BD we re si mi lar to the con trol gro up, but se rum le vels of sIL-2R and TNF-α we re hig her in pa ti ents with BD com pa red to con trols. 20 Our fin dings on se rum IL-6 le vels are inconsistent with tho se of Me ge, Turan, Ya ma ka wa, Na wa ta, Ham za o u i, Eve rek li og lu, Bar dak, Adam, Ak de niz et al, however they are consistent with tho se of al-Da la an, and Sa yi nalp et al 8,[11][12][13][14][15][16][17][18][19][20] The only study in li te ra tu re in which se rum adi no pec tin le vel is in ves ti ga ted in BD was per formed by Oguz et al 22 In this study, se rum adi no pectin le vels we re not sig ni fi cantly dif fe rent in BD in com pa ri son to the he althy con trol gro up. The ir pati ent gro up ma ni fes ted si mi la ri ti es to our pa ti ents be ca u se 86.8% of the pa ti ents used colc hi ci ne, 2.6% used ste ro id and 5.3% used im mu no sup res si ves.…”

“…Bar dak et al de tec ted sig ni fi cantly hig her se rum le vels of IL-6, IL-8 ve TNF-α in BD pa ti ents with ac ti ve uve tis in com pa ri son to the remis si on pe ri od of the sa me pa ti ent gro up and healthy in di vi du als. 16 Adam et al fo und sig ni fi cantly hig her le vels of CRP and IL-6 in the ac ti ve BD pati ent gro up in com pa ri son to the con trol gro up. 17 Ak de niz et al fo und sig ni fi cantly hig her se rum levels of IL-6, IL-8 and TNF-α in BD in com pa ri son to the con trol gro up.…”

“…Many in vi vo stu di es ha ve de mons tra ted that TNF-α, IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, G-CSF and IFN-γ were all im por tant com po nents of the pro inf lam ma tory res pon se in BD. 8,[11][12][13][14][15][16][17][18] Me ge et al fo und that the spon ta ne o us sec re ti on of TNF-α, Turkiye Klinikleri J Med Sci 2010;30 (6) IL-6 and IL-8 by mo nocy tes was sig ni fi cantly incre a sed in pa ti ents with ac ti ve BD. 11 Tu ran et al re por ted that IL-10 and IL-12 were in cre a sed in BD and IL-12 had a cor re la ti on with ac ti va ti on.…”

“…9,10 Stu di es on cyto ki ne pro fi le in BD have yielded conf lic ting re sults. 8,[11][12][13][14][15][16][17][18][19][20] Adi po nec tin is an adi pocy to ki ne which was de fi ned first and it is the major pro te in produced by the adi pocy tes. It is a cen tral re gu la tory pro te in con trol ling li pid and car bohy dra te me ta bo lism in many physi o lo gic path ways and it me di a tes va ri ous vas cu lar pro ces ses.…”

Cytokines and Chemokines in Uveitis - Is there a Correlation with Clinical Phenotype?

“…13 Significantly raised IL-2, IL-6, IFN-γ and TNF-α levels have, however, been found in the aqueous humor and serum of patients with uveitis and BD. 86,88,113 Elevated serum levels of IL-2 receptors, 114 IL-6, IL-8, TNF-α, 115 IFN-γ 116 and MIP-1α 117 have also been found by others, while IL-6 has also been detected in vitreous humor aspirates. 84 Aqueous humor IL-8 detected with the multicytokine assay was significantly increased in comparison with controls.…”