The Dependence of RBE on Energy of Fast Neutrons: 2. Biological Evaluation at Discrete Neutron Energies in the Range 0.43 to 1.80 Mev

Bateman, J. L.; Rossi, Harald H.; Bond, V.P.; Gilmartin, J.

doi:10.2307/3571151

Cited by 27 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experiment, the 1 MeV mean energy mixed neutron-photon beam proved to be 4 times more effective biologically than the 18 MeV mean energy mixed neutronphoton radiation. After the introduction of fast neutron therapy in the sixties, numerous experiments have proven that higher energy neutrons caused less cellular damages, resulting in decreasing RBE in correlation to increasing neutron energies (Bateman et al 1961;Hall et al 1975;Field 1976).…”

Section: Discussionmentioning

confidence: 99%

A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources

Szabó

Reisz

Polanek

et al. 2018

International Journal of Radiation Biology

View full text Add to dashboard Cite

Purpose: The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. Aim: The aim of this paper was to test the relative biological effectiveness (RBE) of the zebrafish embryo system at two neutron facilities. Material and Methods: Series of viable zebrafish embryos at 24-hour post-fertilization (hpf) were exposed to single fraction, whole-body, photon and neutron (reactor fission neutrons () and (p (18 MeV)þBe, ¼ 3.5 MeV) fast neutron) irradiation. The survival and morphologic abnormalities of each embryo were assessed at 24-hour intervals from the point of fertilization up to 192 hpf and then compared to conventional 6 MV photon beam irradiation results. Results: The higher energy of the fast neutron beams represents lower RBE (ref. source LINAC 6 MV photon). The lethality rate in the zebrafish embryo model was 10 times higher for 1 MeV fission neutrons and 2.5 times greater for p (18 MeV)þBe cyclotron generated fast neutron beam when compared to photon irradiation results. Dose-dependent organ perturbations (shortening of the body length, spine curvature, microcephaly, micro-ophthalmia, pericardial edema and inhibition of yolk sac resorption) and microscopic (marked cellular changes in eyes, brain, liver, muscle and the gastrointestinal system) changes scale together with the dose response. Conclusion: The zebrafish embryo system is a powerful and versatile model for assessing the effect of ionizing radiation with different LET values on viability, organ and tissue development.

show abstract

Section: Discussionmentioning

confidence: 99%

A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources

Szabó

Reisz

Polanek

et al. 2018

International Journal of Radiation Biology

View full text Add to dashboard Cite

show abstract

“…For charged particles, equation (7) (1 1) and (12) and is based upon the neutron data of BATEHAN and BOND mentioned above. This equation is as follows:…”

Section: Definition Of Wmentioning

confidence: 99%

The Possible Role of Moment Um in Radiation Dosimetry.-III Remarks on the 1962 ICRP/ICRU Report

Hollister¹,

Je²

1966

Health Physics

View full text Add to dashboard Cite

Work in radiation dosimetry during the last several years has been directed in part toward formulations that bring to bear new experimental techniques and new theoretical ideas. Examples include the work of (1) ROW and co-workers, directed toward finding a detailed description of local energy absorption in tissue, (2) HURST and RITCHIE, directed toward stating formally the problem of dosimetry in the most general way, and (3) TURNER and HOLLISTER, directed toward finding a physical equivalence of different radiations that are made biologically equivalent by producing a given end point experimentally. These investigations have been successful in clarifying some questions. I n particular, the last-named work has shown that linear momentum transfer together with energy transfer describe RBE and the dependence of RBE: on LET. The explicit relationship found, based originally on neutron RBE data, also bears a marked resemblance to an empirical relationship given in the 1962 report of the ICRP/ICRU RBE Committee. A discussion of these results is presented. It is found that they have a unified description in terms of incident particle velocity. The ratio of linear momentum absorbed per unit mass (Pabs) to energy absorbed per unit mass (Eabs) has, of course, the physical dimensions of reciprocal velocity.

show abstract

“…Somatic damages: Figure 2 shows typical examples of RBE-versus-LET curves for somatic damages; chromosome aberrations in Tradescantia (Conger et al 1958) and wheat (Matsumura 1961;, killing of mice (summarized by Storer et al 1957), weight loss of spleen and thymus of mice (Storer et al 1957;Bateman et al 1961), and inactivation of yeast and Shigella sonnei (Brustad 1961 3. RBE-versus-LET curves for genetic effects.…”

Section: Rbe For Somatic Damages and Mutationsmentioning

confidence: 99%

Variation in Mutagenicity and Radiation Resistance With Genome Complexity and Evolution

Kondo

1964

The Japanese journal of genetics

View full text Add to dashboard Cite

The Dependence of RBE on Energy of Fast Neutrons: 2. Biological Evaluation at Discrete Neutron Energies in the Range 0.43 to 1.80 Mev

Cited by 27 publications

References 18 publications

A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources

A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources

The Possible Role of Moment Um in Radiation Dosimetry.-III Remarks on the 1962 ICRP/ICRU Report

Variation in Mutagenicity and Radiation Resistance With Genome Complexity and Evolution

Contact Info

Product

Resources

About