The design of durable Na+-selective CHEMFETs based on polysiloxane membranes

Brunink, J.A.J.; Lugtenberg, R.J.W.; Brzózka, Zbigniew; Engbersen, Johan F.J.; Reinhoudt, David N.

doi:10.1016/0022-0728(94)87071-3

Cited by 54 publications

(28 citation statements)

References 46 publications

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“…The two major obstacles for achieving robust systems are the leaching of membrane components into the sample [2, 199±201], which is usually of lesser concern with macroscopic ISEs, and the construction of a robust inner reference system. Leaching can be avoided by covalent attachment of membrane components to the polymer backbone [202,203]. Depending on the very system, the anchoring of both the ionophore and the ion exchanger sites may [202] or may not [155,203] affect the response slope.…”

Section: Size Limitsmentioning

confidence: 99%

“…Leaching can be avoided by covalent attachment of membrane components to the polymer backbone [202,203]. Depending on the very system, the anchoring of both the ionophore and the ion exchanger sites may [202] or may not [155,203] affect the response slope. To obtain a robust inner reference system, use of the lipophilic complex of a redox-active ion, such as of Ag , in connection with a Ag wire as solid contact, has been proposed [204,205].…”

Section: Size Limitsmentioning

confidence: 99%

See 1 more Smart Citation

Polymer Membrane Ion-Selective Electrodes-What are the Limits?

Bakker¹,

Bühlmann²,

Pretsch³

1999

Electroanalysis

342

197

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This article reviews recent advances in the ®eld of potentiometric solvent polymeric membrane electrodes. These sensors have found widespread applications in a variety of ®elds, especially in the area of clinical diagnostics. Emphasis is given on the discussion of the theoretical and practical limits of ionophore-based ion-selective electrodes, with a special focus on electrode sensitivities, characterization of selectivities and dramatic improvements in detection limits. Advances in ionophore design and in the underlying model assumptions are also discussed. It is shown that a multitude of exciting new research possibilities have recently emerged in this well±established ®eld.

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Section: Size Limitsmentioning

confidence: 99%

Section: Size Limitsmentioning

confidence: 99%

Polymer Membrane Ion-Selective Electrodes-What are the Limits?

Bakker¹,

Bühlmann²,

Pretsch³

1999

Electroanalysis

342

197

View full text Add to dashboard Cite

show abstract

“…They can be either inorganic, focusing on the use of sodium aluminosilicate Na-AlSi 3 O 8 [18,19], either organic, emphasizing the use of sodium ionophores and polymers [20,21]. As far as polymers are concerned, poly-vinyl-chloride (PVC) [22][23][24][25][26], polyurethane (PY) [27,28], polypyrolle (PPy) [29], polysiloxane (PSX) [30][31][32][33] and fluoropolysiloxane (FPSX) [34,35] were studied, demonstrating fundamental differences in terms of physical properties and integration processes. Alternatively, the use of numerous sodium ionophores enabled the development of Na + -sensitive ISE and ISFET microdevices with quasinernstian potentiometric responses.…”

Section: Introductionmentioning

confidence: 99%

Physiological stress monitoring using sodium ion potentiometric microsensors for sweat analysis

Cazalé

Sant²,

Ginot³

et al. 2016

Sensors and Actuators B: Chemical

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In the frame of sweat analysis, two technologies, based on either ISE or ISFET devices, were developed for the implementation of pNa potentiometric microsensors. Both of them demonstrated good sodium ion Na + detection properties with a global sensitivity of around 110 mV/pNa in NaClbased solutions due to the use of an integrated "Ag/AgCl ink" pseudo-reference electrode. Then, in order to deal with in-vivo analysis of sweat natremia, a physiological sweatband prototype was developed, consisting of pNa-ISE and pNa-ISFET electronic detection modules as well as a textilebased sweat pump. Finally, sweating process was studied during series of experiments on twentyfive healthy consenting subjects. The sodium ion concentration [Na + ] was successfully monitored in sweat during various heat exposures, demonstrating a global increase with exercise trial duration. Furthermore, a strong correlation was found between the sweat [Na + ] concentration and the subject's internal temperature θ, allowing monitoring the subject's heat stress state. All in all, the relevance of the Na + ion analysis was demonstrated for the physiological stress monitoring and pNa potentiometric microsensors were shown to be very promising for the development of smart sweatbands.

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“…Several approaches have been proposed to solve such problems including chemical anchoring of PVC membranes containing OH groups to an oxide surface via cross-linking with SiCl 4 [9,10], chemical attachment of sensing membranes to solid surfaces [11][12][13][14][15], use of graphite-epoxy as an internal reference [16], use of adhesive polymer matrices other than PVC [4,5,10,[17][18][19][20] or modifying the oxide surface by means of ion implantation [21].…”

Section: Introductionmentioning

confidence: 99%