The detection of antibody against peste des petits ruminants virus in Sheep, Goats, Cattle and Buffaloes

Khan, Haider Ali; Siddique, M.; Rahman, Sajjad-ur; Abubakar, Muhammad; Ashraf, Muhammad

doi:10.1007/s11250-008-9129-2

Cited by 65 publications

(58 citation statements)

References 18 publications

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“…A difference in the neutralising PPR antibodies in the sheep may be sensitivity to PPR virus, which was correlated to breed because sheep only suffer mild to inapparent infection rather than to the virus, was reported among various with the virus or this may be attributed to a higher breeds of goats [22,23]. PPR is the singular most recovery rate and a greater longevity of sheep verses important cause of morbidity and mortality among goats which is similar to the serological profile small ruminants, for which the most effective form of reported earlier by some workers [30,31,32]. Some protection is through vaccination or an eventful workers have reported a PPR outbreak in a flock of recovery from natural infection.…”

Section: Resultssupporting

confidence: 60%

Seroprevalence of peste des petits ruminants among domestic small and large ruminants in the semi-arid region of north-eastern Nigeria

El-Yuguda¹,

Baba²,

Ambali³

et al. 2013

Vet World

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Background: Recent changes in the host range of peste des petits ruminants (PPR) virus coupled with the presence of a huge ruminant population in the study area has stimulated our interest to carry out a sero-survey for PPR among the different domestic ruminant populations of semi-arid region of North-eastern (NE) Nigeria. Materials and Methods:The prevalence of PPR virus antibodies among domestic animals (goat, sheep, cattle and camel) populations in NE Nigeria was studied using virus neutralisation test (VNT) and competitive enzyme-linked immunosorbent assay (c-ELISA).Results: An overall seroprevalence of 57% and 55% were revealed using VNT and c-ELISA, respectively. Significant difference (p<0.05) in the prevalence of PPR antibodies was noted between the different species of animals tested. Highest seroprevalence of 76.5% was found in sheep followed by a decreasing order of prevalence in goat 51.6%, camels 27.8% and cattle 16.7%. Similar pattern of prevalence was noted when the sera were tested for PPR using c-ELISA antibody. There was no significant difference in the sensitivity of both the procedures (VNT and c-ELISA) when used for the detection of PPR antibody in test sera. However, differences were noted in their specificity based on the degree of cross reactivity between PPR and rinderpest (RP) antibodies. Higher percentage of PPR positive sera (goats 64.8% and sheep 63.8%) cross-reacted with RP virus in VNT. None of the PPR positive sera from cattle and camels cross-reacted with RP virus in VNT and c-ELISA. Significant difference in gender and age was noted in the prevalence of PPR antibody among goats and sheep. Specificall, higher prevalence was found in females and the seroprevalence increased with age among the different age groups of goats studied. Analysis of the seasonal distribution of prevalence of PPR antibody in positive samples did not reveal any significant difference between seasons. Conclusion:We conclude that PPR virus is actively circulating among the ruminant and dromedary populations and that the infection may be endemic in the study area. Significant findings from our study indicate that cattle and camel could play a key role in the epidemiology of PPR, especially in areas like the one under this study where small ruminants are reared alongside cattle and/or camels. Further studies are necessary to fully elucidate, the pivotal roles of cattle and camel in the transmission cycle of PPR virus.

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Section: Resultssupporting

confidence: 60%

Seroprevalence of peste des petits ruminants among domestic small and large ruminants in the semi-arid region of north-eastern Nigeria

El-Yuguda¹,

Baba²,

Ambali³

et al. 2013

Vet World

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“…Specific antigen could be detected in the unvaccinated control animals after challenge but not from any of the immunized goats. The antibody titres against PPR in cattle and buffalo have also been reported by Khan et al (2008). Therefore, it is suggested that, within villages where PPR vaccination is administered in small ruminants, cattle in close contact with sheep/goats could be considered sentinel animals and could be sampled for evidence of seroconversion.…”

Section: Discussionmentioning

confidence: 90%

Post-vaccination antibodies profile against Peste des petits ruminants (PPR) virus in sheep and goats of Punjab, Pakistan

Khan

Siddique

Arshad

et al. 2008

Trop Anim Health Prod

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A total of 70 sheep and 330 goats were selected randomly. All the animals were kept under same housing and management conditions. Serum samples were collected from all the animals and tested for the presence of antibodies against Peste des petits ruminants (PPR) virus using competitive ELISA (cELISA). All the animals were found negative showing percentage inhibition (PI) values <50. The animals were vaccinated against PPR with Nig/75/1 strain vaccine of PPR Serum samples were collected from randomly selected 12 sheep and 30 goats at 10, 30 and 45 days post-vaccination. The samples were subjected to cELISA to determine the presence of antibodies against PPRV. The samples with PI >50 were considered as sero-positive. The sheep found positive at 10, 30 and 45 days post-vaccination were 1(8.3%), 7(58.3%) and 12(100%) respectively. In case of goats 3(10.0%), 29(96.6%) and 27(90.0%) animals gave positive results at 10, 30 and 45 days post-vaccination respectively. Mean PI values in sheep at 10, 30 and 45 days post-vaccination were recorded as 37, 65 and 91 respectively, whereas in goats these values were 43, 78 and 86 respectively.

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“…57,59,62,65,66,67,68,70,72,74,79,80,81,84,86,87,88,89,90,93,94,95,97,98,99,105,106,109,112,113,114,116,117,118,119,120,121,125,126,128,130,131,132,133,135,137,138,139,141,142,145,147,…”

Section: Study Eligibility Form: Performance Of Diagnostic Tests For mentioning

confidence: 99%

Scientific Opinion on peste des petits ruminants

2015

EFSA Journal

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Peste des petits ruminants (PPR) is a severe viral disease of small ruminants caused by a Morbillivirus closely related to rinderpest virus. It is widespread in Africa and Asia and is currently also found in Turkey and Northern Africa. PPR is transmitted via direct contact, and the disease would mainly be transferred to infection-free areas by transport of infected animals. In the EU, it could only happen through illegal transport of animals. The risk of that depends on the prevalence in the country of origin and the number of animals illegally moved. The extent of the spread would depend mainly on the time during which it is undetected, the farm density, the frequency and distance of travel of animals. PPR has a high within-herd transmission rate, therefore contacts between flocks, e.g. through common grazing areas, should be avoided when PPR is present. If PPR enters EU areas with dense sheep population but low goat density, it may spread rapidly undetected, since goats are considered more susceptible than sheep. Effective measures in limiting the spread of PPR in the EU include prompt culling of infected herds, rapid detection, movement restriction, and disinfection. Live attenuated vaccines against PPR are available, safe and effective, and have been successfully used to control PPR epidemics, but no method exists for differentiating between infected and vaccinated animals; therefore, the development of one is recommended. Awareness-raising campaigns for farmers and veterinary staff to promote recognition of the disease should be considered. The cooperation of the EU with neighbouring countries should be encouraged to prevent the spread of PPR and other transboundary diseases. In particular, EFSA was asked to (i) characterise the disease and provide an update on the global occurrence of PPR and changes in the distribution during the last 10 years; (ii) map the region of concern and other countries of the Mediterranean Basin and Black Sea, displaying identified, or likely, major live animal trade routes; (iii) evaluate all possible pathways of introduction of PPR into the EU, ranking them on the basis of their level of risk, with a view to enhancing preparedness and prevention; (iv) assess the risk of introduction and speed of propagation of PPR into the EU and neighbouring countries; (v) assess the risk of PPR becoming endemic in animal populations in the EU; (vi) assess the impact PPR would have if it were to enter the EU, considering different scenarios as regards the effectiveness of surveillance and control measures; and (vii) review the feasibility, availability and effectiveness of the main disease prevention and control measures (diagnostic tools, biosecurity measures, restrictions on movement, culling). © EuropeanRegarding disease characterisation, the AHAW Panel reported that PPR is a severe viral disease of small ruminants caused by a Morbillivirus closely related to rinderpest virus. It is widespread in Africa, the Middle East and Southern Asia. It is one of the priority animal diseases wh...

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The detection of antibody against peste des petits ruminants virus in Sheep, Goats, Cattle and Buffaloes

Cited by 65 publications

References 18 publications

Seroprevalence of peste des petits ruminants among domestic small and large ruminants in the semi-arid region of north-eastern Nigeria

Seroprevalence of peste des petits ruminants among domestic small and large ruminants in the semi-arid region of north-eastern Nigeria

Post-vaccination antibodies profile against Peste des petits ruminants (PPR) virus in sheep and goats of Punjab, Pakistan

Scientific Opinion on peste des petits ruminants

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