A study of the water quality of the Adolfo López Mateos Reservoir (ALMD) was developed through different indicators from a spatial and seasonal perspective. Variables related to the general characteristics of water quality, trophic level, and ecological risk were assessed through the National Sanitation Foundation–Brown Water Quality Index (WQINSF–BROWN), the Carlson Trophic State Index (TSICARLSON) and the Håkanson Ecological Risk Index (RIHÅKANSON). Using data from physical, chemical, and biological parameters obtained from four sampling points in the ALMD, the water quality was assessed in each model used. The results indicated that the reservoir presents a water quality classified as “medium” (WQINSF–BROWN = 70), where significant variations in the concentrations of some parameters are observed. The reservoir showed a general trophic state (TSIGENERAL-AVERAGE = 43.04) classified as “mesotrophic”. The ecological risk analysis achieved the best classification of the methodology, discarding contamination by heavy metals in surface waters. This type of applied methodology will help in decision-making tools in the dam, and can be applied in other dams in the region.