The Detrimental Effect of Frequent Transfusions in the Treatment of a Patient With Hemophilia

A circulating anticoagulant in gamma-1A-multiple myeloma: its modification by penicillin.

“…6 Fraction 4 was the first found to contain measurable protein, and is indicated on the graph in the number one position. O myeloma plasma plus saline; X X myeloma plasma plus equal volume of undiluted specific anti-'ylA-antiserum; A -A myeloma plasma plus antiserum diluted 1/10; *-0* myeloma plasma plus antiserum diluted 1/20 Figure 5, where alteration of the mobility of the albumin in the patient's serum is shown, apparently due to complex formation with the myeloma protein (33 (34)(35)(36)(37), and in postpartum patients (38,39). They have been observed in patients with penicillin reactions (1,40), and in pemphigus (41).…”

Properties of an Anticoagulant Found in the Blood of a Hemophiliac

“…These are: (1) the properties of the anticoagulant in unfractionated plasma, (2) the relation of the anticoagulant to the various factors involved in the coagulation mechanism, and (3) The patient's plasma was mixed with twice its volume of normal plasma and incubated at 37°C. At intervals, as shown in Table II, 0.6 ml.…”

Le rôle des inhibiteurs faibles du facteur VIII

“…La littérature des inhibiteurs du facteur VIII est devenue considé rable [17,26] depuis que L o z n e r et al [16] en publièrent le premier cas spontané et que M u n r o et J o n es [19] les trouvèrent chez l'hémo phile classique A. Aujourd'hui, la plupart des auteurs les considèrent comme des anticorps (29,14), 7 S y-globulines [1,28] associés à des 19 S y-M globulines [30], Ig globulines à chaînes légères, semblables aux autoanticorps froids des anémies hémolytiques [27]. Cependant tous ne sont peut-être pas des y-globulines [24,25].…”