The developing brain as an endocrine source of norepinephrine in the blood

Saifetyarova, Yu. Yu.; Melnikova, V. I.; Sapronova, A. Ya.; Volina, E. V.; Ugrumov, M. V.

doi:10.1134/s0012496614010116

Cited by 5 publications

(4 citation statements)

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“…This role involves their vesicular secretion by the pre-synaptic cell and interaction with receptors on the post-synaptic cell. However, neurotransmitters are also released outside synapses in high concentrations prior to blood-brain barrier development 21 , 22 and as part of non-synaptic forms of intercellular communication in the mature brain 23 . Synaptic transmission requires the rapid clearance of the secreted or released neurotransmitter via uptake by neurons and astrocytes 24 .…”

Section: Neurotransmitter Toxicity and Its Implication In Neurodegenementioning

confidence: 99%

Why are neurotransmitters neurotoxic? An evolutionary perspective

2014

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In the CNS, minor changes in the concentration of neurotransmitters such as glutamate or dopamine can lead to neurodegenerative diseases. We present an evolutionary perspective on the function of neurotransmitter toxicity in the CNS. We hypothesize that neurotransmitters are selected because of their toxicity, which serves as a test of neuron quality and facilitates the selection of neuronal pathways. This perspective may offer additional explanations for the reduction of neurotransmitter concentration in the CNS with age, and suggest an additional role for the blood-brain barrier. It may also suggest a connection between the specific toxicity of the neurotransmitters released in a specific region of the CNS, and elucidate their role as chemicals that are optimal for testing the quality of cells in that region.

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Section: Neurotransmitter Toxicity and Its Implication In Neurodegenementioning

confidence: 99%

Why are neurotransmitters neurotoxic? An evolutionary perspective

2014

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“…We have earlier shown in in vitro experiments that dopamine, at the concentration at which it is present in the peripheral blood of neonatal rats, inhibits prolactin secretion by the pituitary gland [10, 14]. However, pituitary cells are under the constant tonic influence of DA under in vivo conditions, while in in vitro conditions, the pituitary cells are contained in a medium without DA for a long period of time, which, according to some scientists, can fundamentally change cell physiology [15].…”

Section: Discussionmentioning

confidence: 99%

“…In adult animals, DA transferred from the hypothalamus to the pituitary gland regulates the function of peripheral targets only through the portal circulation system, whereas, according to our hypothesis, DA, in the absence of BBB in neonatal animals, can be also transferred from all populations of neurons directly into the systemic circulation. We have earlier shown in in vitro experiments that dopamine, at the concentration at which it is present in the peripheral blood of neonatal rats, inhibits prolactin secretion by the pituitary gland [ 10 , 14 ]. However, pituitary cells are under the constant tonic influence of DA under in vivo conditions, while in in vitro conditions, the pituitary cells are contained in a medium without DA for a long period of time, which, according to some scientists, can fundamentally change cell physiology [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Dopamine Secreted by the Brain into the Systemic Circulation on Prolactin Synthesis by the Pituitary gland in Ontogenesis

2016

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This research was aimed at studying the brain’s endocrine function in ontogenesis. It has been previously shown in our laboratory that the brain serves as the source of dopamine in the systemic circulation of rats prior to the formation of the blood-brain barrier. This paper provides direct evidence that dopamine secreted by the brain directly into the systemic circulation in this period of ontogenesis has an inhibitory effect on prolactin secretion by pituitary cells. These results provide the basis for a fundamentally new understanding of the brain’s role in the neuroendocrine regulation of the development and function of peripheral target organs and, particularly in this study, the pituitary gland.

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