The developing intestinal microbiome and its relationship to health and disease in the neonate

R, Murgas Torrazza; Neu, J.

doi:10.1038/jp.2010.172

Cited by 168 publications

(118 citation statements)

References 69 publications

(84 reference statements)

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“…Recovery stools had a lesser relative abundance of Lactobacillus, thought to be a marker of a healthy microbiome. 26,27 While this finding was unexpected, a previous study of Indian children found that the abundance of Lactobacillus species increased at the end of diarrhea episodes and then decreased after 3 months of recovery. 28 Also, as compared with diarrhea stools, recovery stools had a greater relative abundance of genera of the order Clostridiales (Dorea, Blautia, Dialister, and Sporobacterium WAL_1855D).…”

Section: Discussionmentioning

confidence: 53%

Gut Microbiome Composition in Young Nicaraguan Children During Diarrhea Episodes and Recovery

Becker‐Dreps¹,

Allali²,

Monteagudo³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Understanding how the gut microbiota is affected by diarrhea episodes may help explain alterations in intestinal function among children in low-income settings. This study examined the composition of the gut microbiome of Nicaraguan children both during diarrhea episodes and while free of diarrhea for at least 2 months. Relative abundances of bacterial taxa, phylogenetic diversity, and species richness were determined by 16S amplicon sequencing and compared between paired diarrhea and recovery samples. A total of 66 stools were provided by 25 children enrolled in a 1-year cohort study of diarrhea etiologies. Children in our cohort had a mean age of 21.9 months; 64% were breast-fed, and 10% had received an antibiotic during the diarrhea episode. Overall, phylogenetic diversity and species richness did not differ significantly between diarrhea and recovery stools. However, of children who had a bacterial enteropathogen detected in any diarrhea stool, none experienced an increase in phylogenetic diversity in recovery, whereas of those in whom no bacterial enteropathogens were detected in their diarrhea stool(s), 59% experienced an increase in phylogenetic diversity in recovery (P = 0.008). This preliminary study suggests that recovery of the gut microbiota after a diarrhea episode may take longer time than previously thought and may be pathogen specific.

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Section: Discussionmentioning

confidence: 53%

Gut Microbiome Composition in Young Nicaraguan Children During Diarrhea Episodes and Recovery

Becker‐Dreps¹,

Allali²,

Monteagudo³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Current data do not permit a predictive model of microbial gut colonization based on specific variables, but models proposed in future studies must account for dynamism in microbial populations, which obligates serial sampling of as many specimens as possible in future efforts to relate the premature infant intestinal biomass to various host diseases and phenotypes (41). These properties also provide an argument for very intensive and extensive sampling of control populations in this age group, and for the incorporation of computational analyses that address community changes over time (42) in dynamic microbial populations (43).…”

Section: Discussionmentioning

confidence: 99%

Patterned progression of bacterial populations in the premature infant gut

Rosa¹,

Warner

Zhou³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

483

524

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The authors note that on page 12527, left column, second full paragraph, line 7, "Sequences meeting the above criteria were further classified by the Ribosomal Database Project (RDP) Naive Bayesian Classifier version 2.5 using training set 9 (46) from phylum to genus level." should instead appear as "Sequences meeting the above criteria were further classified by the Ribosomal Database Project (RDP) Naive Bayesian Classifier version 2.2 using training set 6 (46) from phylum to genus level."www.pnas.org/cgi

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“…Все эти изменения могут играть определенную роль в нару-шении процессов формирования толерантности слизистой оболочки [20,21,26] и реализации генетической пред-расположенности к аллергии [27]. Напротив, естествен-ное вскармливание дает важные преимущества, в число которых входит адекватная стимуляция иммунной системы и обеспечение нормальной кишечной флорой [28].…”

Section: кишечный микробиоценоз и здоровье ребенкаunclassified

“…Существенные различия в микрофлоре младен-цев, находящихся на грудном или искусственном вскарм-ливании, выявляют и культуральными, и молекулярно-генетическими методами исследования [28,37]. При этом показано, что при грудном вскармливании в биоценозе кишки преобладают Bacteroides, а при искусственном -Firmicutes и Verrucomicrobia.…”

Section: возраст ребенка кишечный эпителий микробиота кишкиunclassified

Prebiotics as a «functional» Component of Child Nutrition

Макарова¹

2013

Vopr. sovr. pediatr.

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Человек живет в сообществе с многочисленными видами микробов, количество которых, по разным оцен-кам, как минимум на порядок превышает число клеток самого человека. Соответственно, только 10% клеток, входящих в состав организма, являются собственно человеческими, остальные же примерно 90% принад-лежат бактериям, населяющим различные биотопы человека [1]. Состояние макроорганизма, его питание и окружающая среда в значительной степени сказы-ваются на микробиоценозе. Микробные сообщества, в свою очередь, определяют иммунитет и устойчивость к патогенам и влияют на здоровье человека через раз-личные процессы, связанные со всеми видами обмена макро-и микронутриентов [1][2][3][4][5][6].В результате организм человека в настоящее вре-мя рассматривают как суперорганизм, т. е. совокуп-ность большого числа живых существ, функционирующих как единое целое [6]. Значительный прорыв в пони-мании микробиоценоза был сделан благодаря раз-витию новых молекулярно-генетических технологий, которые позволили идентифицировать многочисленные виды бактерий, не поддающиеся культивированию. Для исследования микробной популяции в настоящее время используют метод секвенирования (определение нуклео-

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The developing intestinal microbiome and its relationship to health and disease in the neonate

Cited by 168 publications

References 69 publications

Gut Microbiome Composition in Young Nicaraguan Children During Diarrhea Episodes and Recovery

Gut Microbiome Composition in Young Nicaraguan Children During Diarrhea Episodes and Recovery

Patterned progression of bacterial populations in the premature infant gut

Prebiotics as a «functional» Component of Child Nutrition

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