To meet the practical application requirements of cardiac fixation during off-pump coronary artery bypass surgery, a soft cardiac fixator with a flexible arm was previously designed. To enable the soft cardiac fixator to adapt to uncertain external forces, this study evaluates the variable-stiffness performance of the flexible arm. First, the flexible arm was simplified as a soft silicone manipulator measuring 60 mm × 90 mm × 120 mm, which can actuate, soften, or stiffen independently along the length of the arm by combining granular jamming with input pressure. Then, the soft manipulator was modelled as a cantilever beam to analyse its variable-stiffness performance with granular jamming. Next, based on theoretical analysis and calculations, many experiments were conducted to evaluate the variable-stiffness performance of the soft manipulator. The experimental results demonstrated that the variable-stiffness performance is influenced by the flexible arm length, the size of the granules, and the input pressure.