The Development and Growth of Tissues Derived from Cranial Neural Crest and Primitive Mesoderm Is Dependent on the Ligation Status of Retinoic Acid Receptor γ: Evidence That Retinoic Acid Receptor γ Functions to Maintain Stem/Progenitor Cells in the Absence of Retinoic Acid

Wai, Htoo A.; Kawakami, Koichi; Wada, Hironori; Müller, Ferenc; Vernallis, Ann B.; Brown, Geoffrey; Johnson, William E.

doi:10.1089/scd.2014.0235

Cited by 16 publications

(9 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RA and FGF signaling pathways also function together to pattern the posterior portion of embryos and control NC migration (Martinez-Morales et al, 2011). For example, knockdown of the RA receptor-Υ causes defects in NC progenitor cells in zebrafish embryos in addition to aberrant paraxial mesoderm development (Wai et al, 2015). There are contrasting studies with regards to RA in NC development.…”

Section: Retinoic Acidmentioning

confidence: 99%

Specifying neural crest cells: From chromatin to morphogens and factors in between

Rogers

Nie

2018

WIREs Developmental Biology

View full text Add to dashboard Cite

Neural crest (NC) cells are a stem-like multipotent population of progenitor cells that are present in vertebrate embryos, traveling to various regions in the developing organism. Known as the "fourth germ layer", these cells originate in the ectoderm between the neural plate (NP), which will become the brain and spinal cord, and nonneural tissues that will become the skin and the sensory organs. NC cells can differentiate into more than 30 different derivatives in response to the appropriate signals including, but not limited to, craniofacial bone and cartilage, sensory nerves and ganglia, pigment cells, and connective tissue. The molecular and cellular mechanisms that control the induction and specification of NC cells include epigenetic control, multiple interactive and redundant transcriptional pathways, secreted signaling molecules, and adhesion molecules. NC cells are important not only because they transform into a wide variety of tissue types, but also because their ability to detach from their epithelial neighbors and migrate throughout developing embryos utilizes mechanisms similar to those used by metastatic cancer cells. In this review, we discuss the mechanisms required for the induction and specification of NC cells in various vertebrate species, focusing on the roles of early morphogenesis, cell adhesion, signaling from adjacent tissues, and the massive transcriptional network that controls the formation of these amazing cells. This article is categorized under: Nervous System Development > Vertebrates: General Principles Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms Gene Expression and Transcriptional Hierarchies > Gene Networks and Genomics Signaling Pathways > Cell Fate Signaling.

show abstract

Section: Retinoic Acidmentioning

confidence: 99%

Specifying neural crest cells: From chromatin to morphogens and factors in between

Rogers

Nie

2018

WIREs Developmental Biology

View full text Add to dashboard Cite

show abstract

“…Treatment of zebrafish embryos with a RARγ-specific agonist adversely affected the development and growth of tissues that form from neural crest and lateral plate mesodermal stem and progenitor cells that express RARγ. These studies revealed that RARγ, which can play a role in cell reprogramming, has to be inactive at the stem/progenitor stage of development for these cells to make an appropriate decision to differentiate along a pathway [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?

Brown

Sánchez-Garcı́a

2015

Oncotarget

Self Cite

View full text Add to dashboard Cite

Within the past years there have been substantial changes to our understanding of haematopoiesis and cells that initiate and sustain leukemia. Recent studies have revealed that developing haematopoietic stem and progenitor cells are much more heterogeneous and versatile than has been previously thought. This versatility includes cells using more than one route to a fate and cells having progressed some way towards a cell type retaining other lineage options as clandestine. These notions impact substantially on our understanding of the origin and nature of leukemia. An important question is whether leukemia stem cells are as versatile as their cell of origin as an abundance of cells belonging to a lineage is often a feature of overt leukemia. In this regard, we examine the coming of age of the “leukemia stem cell” theory and the notion that leukemia, like normal haematopoiesis, is a hierarchically organized tissue. We examine evidence to support the notion that whilst cells that initiate leukemia have multi-lineage potential, leukemia stem cells are reprogrammed by further oncogenic insults to restrict their lineage decision-making. Accordingly, evolution of a sub-clone of lineage-restricted malignant cells is a key feature of overt leukemia.

show abstract

“…Findings from studies of zebrafish development further support the view that RARγ activity is important for the maintenance of stem/progenitor cell populations [ 57 ]. In zebrafish, there are two major RAR isotypes, RARα and RARγ, and treatment of zebrafish embryos four hours post-fertilization with the RARγ-selective agonist AGN205327 blocked the development and growth of tissues that are derived from cranial neural crest and primitive mesoderm.…”

Section: Rarγ Is a Fundamental Control On Stem Cell Behaviormentioning

confidence: 72%

The RARγ Oncogene: An Achilles Heel for Some Cancers

Brown

Petrie

2021

IJMS

Self Cite

View full text Add to dashboard Cite

Cancer “stem cells” (CSCs) sustain the hierarchies of dividing cells that characterize cancer. The main causes of cancer-related mortality are metastatic disease and relapse, both of which originate primarily from CSCs, so their eradication may provide a bona fide curative strategy, though there maybe also the need to kill the bulk cancer cells. While classic anti-cancer chemotherapy is effective against the dividing progeny of CSCs, non-dividing or quiescent CSCs are often spared. Improved anti-cancer therapies therefore require approaches that target non-dividing CSCs, which must be underpinned by a better understanding of factors that permit these cells to maintain a stem cell-like state. During hematopoiesis, retinoic acid receptor (RAR) γ is selectively expressed by stem cells and their immediate progeny. It is overexpressed in, and is an oncogene for, many cancers including colorectal, renal and hepatocellular carcinoma, cholangiocarcinomas and some cases of acute myeloid leukemia that harbor RARγ fusion proteins. In vitro studies suggest that RARγ-selective and pan-RAR antagonists provoke the death of CSCs by necroptosis and point to antagonism of RARγ as a potential strategy to treat metastatic disease and relapse, and perhaps provide a cure for some cancers.

show abstract

The Development and Growth of Tissues Derived from Cranial Neural Crest and Primitive Mesoderm Is Dependent on the Ligation Status of Retinoic Acid Receptor γ: Evidence That Retinoic Acid Receptor γ Functions to Maintain Stem/Progenitor Cells in the Absence of Retinoic Acid

Cited by 16 publications

References 67 publications

Specifying neural crest cells: From chromatin to morphogens and factors in between

Specifying neural crest cells: From chromatin to morphogens and factors in between

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?

The RARγ Oncogene: An Achilles Heel for Some Cancers

Contact Info

Product

Resources

About