The Development of a Code of Practice for the Radiation Sterilisation of Tissue Allografts

Parsons, Barry J.; Kairiyama, E.; Phillips, Glyn O.

doi:10.1533/9781845690779.1.39

Cited by 3 publications

(1 citation statement)

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“…Application of these principles of sterilisation to tissue allografts was undertaken by the International Atomic Energy Agency through a project involving tissue banks in Asia and Central and South America (IAEA 2004;Parsons et al 2005). Unlike manufactured health care products, tissue allografts such as amnion and bones have irregular sizes and shape.…”

Section: Principles Of Sterilisation Of Health Care and Related Productsmentioning

confidence: 99%

Free radical studies of components of the extracellular matrix: contributions to protection of biomolecules and biomaterials from sterilising doses of ionising radiation

Parsons

2017

Cell Tissue Bank

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The purpose of the current review is show how the principles and techniques of radiation chemistry have enabled the direct reactions of free radicals with biomolecules and biomaterials to be investigated at the molecular level. In particular, the review focusses on the free radical-induced fragmentation of glycosaminoglycans. Glycosaminoglycans are large linear polysaccharides consisting of repeating disaccharide units and are important components of the extracellular matrix (ECM) either in free form (hyaluronan) or as a component of proteoglycans. Oxidative damage of the extracellular matrix components by either enzymatic or non-enzymatic pathways may have implications for the initiation and progression of a range of human diseases. These include arthritis, kidney disease, cardiovascular disease, lung disease, periodontal disease and chronic inflammation. Oxidative damage to hyaluronan by reactive oxidative species and thus the potential mechanism of damage to the ECM and its role in human pathologies is reviewed with particular focus on damage initiated by potential in vivo free radicals such as superoxide, carbonate and hydroxyl radicals. Such knowledge has also allowed radiation protecting systems to be developed so that sterilising doses of radiation can be delivered to sensitive biomolecules such as proteins and glycosaminoglycans, and also to sensitive biomaterials such as tissue allografts.

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Section: Principles Of Sterilisation Of Health Care and Related Productsmentioning

confidence: 99%

Free radical studies of components of the extracellular matrix: contributions to protection of biomolecules and biomaterials from sterilising doses of ionising radiation

Parsons

2017

Cell Tissue Bank

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Overview on radiation and tissue banking in Latin America

Kairiyama

Pardo

Noda³

et al. 2018

Cell Tissue Bank

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The International Atomic Energy Agency (IAEA) played an important role in the establishment of new tissue banks and the improvement of already existing ones in Latin America. The Agency strongly supported, through regional, interregional and national technical cooperation projects, providing equipment, expert missions and training for the production and application of human tissues for transplantation. From 1999 to 2005 five regional courses were given in Buenos Aires under the modality of 1-year distance learning training courses and 1-week face to face courses. The courses were organized by the IAEA, through the National Atomic Energy Commission (CNEA) and the Faculty of Medicine of Buenos Aires University as Post Graduate Specialization Course. In 2005 the Latin American countries joined with Spain and Portugal, and created the Ibero American Network Council of Donation and Transplant (Red Consejo Iberoamericano de Donación y Trasplantes-RCIDT). The objective of this network is to cooperate among twenty-one Ibero American countries in organizational and legislative aspects, training of professionals, and ethical and social issues related to the donation and transplantation of organs, tissues and cells. The members of this Network work actively to harmonize the regulations and the control of donation and transplantation of human organs, tissues and cells. At present, in Latin America, more than 220 facilities of tissues banks are operating and tissue allografts are being produced by single and multi-tissue banks. The efforts made by the governments and professionals from the region allow the tissue banks to operate under quality systems and introduce new technologies.

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Sterilisation of drug–device combination products

Parsons

2010

Drug-Device Combination Products

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The Development of a Code of Practice for the Radiation Sterilisation of Tissue Allografts

Cited by 3 publications

References 63 publications

Free radical studies of components of the extracellular matrix: contributions to protection of biomolecules and biomaterials from sterilising doses of ionising radiation

Free radical studies of components of the extracellular matrix: contributions to protection of biomolecules and biomaterials from sterilising doses of ionising radiation

Overview on radiation and tissue banking in Latin America

Sterilisation of drug–device combination products

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