The Development of a Systematic Method for Toxicological Research Using an Integrated Multidisciplinary Approach

Wiberg, Gunnar; Coldwell, Blake B.; Trenholm, H. L.

doi:10.3109/15563657108990150

Clinical Toxicology

1971

DOI: 10.3109/15563657108990150

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The Development of a Systematic Method for Toxicological Research Using an Integrated Multidisciplinary Approach

Gunnar Wiberg¹,

Blake B. Coldwell²,

H. L. Trenholm³

Abstract: NO PART of this work may be reproduced or utilized in any form by any means, electronic or mechanical including xerography, photocopying, microfilm, and recording, or by any information storage and retrieval system, without the written permission of the publisher.Clinical Toxicology Downloaded from informahealthcare.com by Chulalongkorn University on 01/08/15For personal use only.

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1972

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Cited by 2 publications

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Some effects of ethanol on the toxicity and distribution of barbiturates in rats

Coldwell¹,

Wiberg²,

Trenholm³

1970

Can. J. Physiol. Pharmacol.

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1970. Some effects of ethanol on the toxicity and distribution of barbiturates in rats. Can. J. Physiol. PharmacoH. 48,[254][255][256][257][258][259][260][261][262][263][264] The interaction of ethanol with amobarbital, barbital, pentobarbital, phenobarbital, and thiopental was investigated at both the pharmacological and metabolic levels in rats. Induction time was shortened and sleeping time lengthened by the administration of ethanol with each of the five barbiturates, the effects being most pronounced with barbital and phenobarbital. Brain levels of barbital, phenobarbital, acetaldehyde, and acetone were increased by ethanol. Rats given amobarbital, pentobarbital, and thiopental had significantly higher brain and scrum barbiturate levels at the time of regain of the righting reflex than was present in rats given these barbiturates with ethanol, indicating that the CNS depression was not dependent only on the concentration of barbiturate in the brain. The decay profiles of serum barbiturate concentrations were not altered by ethanol, and the barbiturates had no effect on the brain and blood ethanol levels. Phenobarbital depressed blood and brain acetaldehyde levels, but not the acetone levels, in ethanol-treated animals. Pentobarbital and thiopental, alone or with ethanol, had no effect on the blood acetaldehyde levels but increased the brain acetaldehyde levels in ethanol-treated animals. Pentobarbital had no effect on blood acetone or acetaldehyde levels but increased the brain levels s f these compounds and, when administered with ethanol, decreased the brain acetone concentration. Thiopental increased the blood acetone level and when administered to ethanol-treated animals decreased the brain acetone levds. COLDWELL, B. B., WIBERG, G. S,, AND 'IXENHOLM, H. L. 1970. Some effects of ethanol on the toxicity and distribution of barbiturates in rats. Can. J. Physiol. Pharrnacoll. 48, 254-264.

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Some effects of ethanol on the toxicity and distribution of barbiturates in rats

Coldwell¹,

Wiberg²,

Trenholm³

1970

Can. J. Physiol. Pharmacol.

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The Changing Role Of Pathology In Modern Safety Evaluation

Grice

Carlson

1972

CRC Critical Reviews in Toxicology

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The Development of a Systematic Method for Toxicological Research Using an Integrated Multidisciplinary Approach

Cited by 2 publications

References 11 publications

Some effects of ethanol on the toxicity and distribution of barbiturates in rats

Some effects of ethanol on the toxicity and distribution of barbiturates in rats

The Changing Role Of Pathology In Modern Safety Evaluation

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