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Known volumes of 70-proof distilled spirits were fed to 68 volunteers, making a total of 141 separate doses. The amount of alcohol appearing in the venous blood, saliva, and urine at various time intervals after ingestion was determined by a modified Widmark method, and in the breath by the Breathalyzer. The relationship between time after ingestion, venous blood alcohol concentration (VBA), and Breathalyzer reading (BR) was as follows:(1) between 0.5 and 2.5 hours after ingestion, VBA = (BR + 0.048) ± 0.124 mg/ml;(2) between 30 to 40 minutes after ingestion, VBA = (BR − 0.071) ± 0.065 mg/ml;(3) between 2 to 2.5 hours after ingestion, VBA = (BR + 0.102) ± 0.117 mg/ml. The weighted average ratios of saliva and urine alcohols to venous blood alcohol were 1.12:1 and 1.24:1, respectively. The standard error of estimating the venous blood alcohol indirectly from the saliva alcohol was ±0.075 mg/ml, and from urine alcohol ±0.081 mg/ml when the samples were obtained from 0.5 to 2.5 and from 0.75 to 2.5 hours after drinking, respectively. Over the range of concentrations studied alcohol disappeared from the venous blood at the rate of 0.13 ±0.05 mg/ml/hr and the quantity eliminated from the whole body, per 100 lb of body weight per hour, approximated 0.4 fl. oz of 70-proof distilled spirits.

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