The development of a wireless LCP-based intracranial pressure sensor for traumatic brain injury patients

Abstract

Raised intracranial pressure (ICP) in traumatic brain injury (TBI) patients can lead to death. ICP measurement is required to monitor the condition of a patient and to inform TBI treatment. This work presents a new wireless liquid crystal polymer (LCP) based ICP sensor. The sensor is designed with the purpose of measuring ICP and wirelessly transmitting the signal to an external monitoring unit. The sensor is minimally invasive and biocompatible due to the mechanical design and the use of LCP. A prototype sensor and associated wireless module are fabricated and tested to demonstrate the functionality and performance of the wireless LCP-based ICP sensor. Experimental results show that the wireless LCP-based ICP sensor can operate in the pressure range of 0 - 60.12 mmHg. Based on repeated measurements, the sensitivity of the sensor is found to be 25.62 µVmmHg-1, with a standard deviation of ± 1.16 µVmmHg-1. This work represents a significant step towards achieving a wireless, implantable, minimally invasive ICP monitoring strategy for TBI patients.

Liquid Crystalline Polymers: Opportunities to Shape Neural Interfaces

“…The low moisture permeability, chemical inertness, flexibility, and suitability for microfabrication of LCPs have enabled the development and demonstration of intracranial pressure sensors (Fig. 1A) (50)(51)(52) and intraocular pressure sensors (53,54). In addition, Simonov et al reported the use of LCP for an adaptive intraocular lens with a superior accommodative power of +2.5 diopter, when compared to the majority of existing single-power accommodating intraocular lens (55).…”

Features measurement analysis of pull-in voltage for embedded MEMS

“…This property of the MEMS switch can be applied to radio frequencies (RF), hence the name RF-MEMS switch [5]. For example, RF-MEMS filters and resonators are intended for applications such as duplex filters, RX&TX band filters, global positioning system (GPS) filters, VCOs, reconfigurable antennas and reference oscillators [6]- [8]. The other application field is RF-MEMS switches, which are very interesting for multi-system phones and with IoT [9], [10].…”