The development of carcinoma of the large intestine in ulcerative colitis

Dawson, I. M. P.; Pryse‐Davies, J.

doi:10.1002/bjs.18004720202

Cited by 145 publications

(37 citation statements)

References 17 publications

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“…Primary malignant lymphomas of the intestinal tract are frequently multiple, and in the series of 38 cases reported by Dawson et al (1960) there were eight cases of this type. The occurrence of malignant lymphoma and adenocarcinoma of the intestinal tract in the same patient, on three occasions, is, however, a most unusual and remarkable finding.…”

mentioning

confidence: 99%

Multiple Primary Cancers: Primary Malignant Lymphomas and Carcinomas of the Intestinal Tract in the Same Patient

Cornes¹

1960

J Clin Pathol

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Three cases of primary malignant lymphoma and primary mucus-secreting adenocarcinoma of the intestinal tract, occurring in the same patients, are described, and three similar cases reported in the literature are discussed. The carcinomas were present at the same time as the lymphomas, or developed after the lymphomas had been removed. The relationship between malignant lymphoma and carcinoma is uncertain, but there is some evidence to suggest a possible relationship between them. It is important not to assume that a second growth in the intestinal tract is always a recurrence or a metastasis from the original primary tumour.

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confidence: 99%

Multiple Primary Cancers: Primary Malignant Lymphomas and Carcinomas of the Intestinal Tract in the Same Patient

Cornes¹

1960

J Clin Pathol

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“…None of these early studies censor non-cancer-related deaths from the relative risk numerator or the survival data. The higher overall mortality rates in adults and children with UC with and without malignancy were, however, well documented during this time period [12][13][14][15][16][17][18].…”

Section: Cancer Risk In Ulcerative Colitismentioning

confidence: 89%

Cancer and Inflammatory Bowel Disease: Bias, Epidemiology, Surveillance, and Treatment

Solomon

Schnitzler

1998

World j. surg.

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Individuals with chronic ulcerative colitis are at increased risk of developing colorectal carcinoma, particularly if there is long-standing disease or extensive colitis. It is generally accepted that the risk of colorectal cancer does not begin until 8 to 10 years after the time of diagnosis of ulcerative colitis. Thereafter it increases by approximately 0.5% to 1.0% per year. In patients with Crohn's disease, the risk of malignancy is smaller and less well defined. The most significant predictor of the risk of malignancy in patients with inflammatory bowel disease is the presence of dysplasia in colonic biopsies. There is considerable controversy in the literature regarding the efficacy of colonoscopic surveillance programs and the role of prophylactic surgery to prevent colorectal cancer. Surveillance certainly fails to detect carcinoma in some patients who are having regular colonoscopy. Concerns have also been raised as to the cost-benefit of colonoscopic surveillance in patients with colitis. Randomized controlled trials of surveillance programs are highly unlikely in view of the low prevalence of IBD in the population, the long period of observation required, and the probability of contamination of surveillance programs by colonoscopy for assessment of disease activity. Despite the lack of clear guidelines, surveillance colonoscopy and biopsy continues to be widely practiced. Research is proceeding to identify genetic and biochemical markers that may prove clinically useful for predicting cancer risk. At present, however, surveillance programs are likely to continue according to institutional practice. It is important for those participating in such programs to be aware of the limitations of colonoscopy and biopsy as a means of reducing the risk of cancer in inflammatory bowel disease.

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“…11 Following this description, other retrospective studies also described adenoma-like dysplastic lesions in UC that were grossly visible or elevated, and the term "DALM" (dysplasia associated lesion or mass) was coined in 1981. 12 In the defining study of 112 UC patients, DALMs were associated with invasive carcinoma in 58% of cases, and therefore were considered a strong indicator for colectomy.…”

Section: Macroscopic Classification Of Dysplasiamentioning

confidence: 95%

Classification and diagnosis of colorectal dysplasia in inflammatory bowel disease

Lam-Himlin

Bhaijee

Arnold

2015

Diagnostic Histopathology

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The development of carcinoma of the large intestine in ulcerative colitis

Cited by 145 publications

References 17 publications

Multiple Primary Cancers: Primary Malignant Lymphomas and Carcinomas of the Intestinal Tract in the Same Patient

Multiple Primary Cancers: Primary Malignant Lymphomas and Carcinomas of the Intestinal Tract in the Same Patient

Cancer and Inflammatory Bowel Disease: Bias, Epidemiology, Surveillance, and Treatment

Classification and diagnosis of colorectal dysplasia in inflammatory bowel disease

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