The Development of Extranodal Lymphoid Follicles in Experimental Bronchopneumonia

Watanabe, Shaw; Ohishi, Takao; Kageyama, Keizo

doi:10.1111/j.1440-1827.1979.tb00922.x

Cited by 6 publications

(8 citation statements)

References 15 publications

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“…A comparison of their ultrastructural characteristics with those of IDRCs shows that DRCs are different cells, apparently not of monocyte derivation. Other authors come to a similar conclusion (Milanesi 1965, Izard & de Harven 1968, Nossal et al 1968, Szakal & Hanna 1968, Mollo et al 1969, Carr 1975, Hoefsmit 1975, Chen et al 1978, Silberberg-Sinakin et al 1980, Heusermann et al 1980, Watanabe et al 1979. In this context, the existing nomenclature (Lennert et al 1978) which names both dendritic and interdigitating cell types 'reticulum cells' may create some confusion.…”

Section: Discussionmentioning

confidence: 67%

“…Until now, DRCs were described in the germinal centres of lymphoid tissues, the so-called B-regions, as well as in malignant lymphomas (Naiem et al 1983). In one report they were mentioned in extranodal lymphoid follicles in experimental bronchopneumonia (Watanabe et al 1979). The DRCs in follicle-like portal accumulations in chronic active hepatitis correspond in all respects to the previous descriptions of DRCs in germinal centres of lymph nodes (Nossal et al 1968, Chen el al.…”

Section: Discussionmentioning

confidence: 69%

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Interdigitating and dendritic reticulum cells in chronic active hepatitis

Bardadin

Desmet

1984

Histopathology

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An ultrastructural study of the cytology of piecemeal necrosis in 12 liver biopsies from patients with chronic active (aggressive) hepatitis revealed a variety of cell types. This communication deals with two particular cell types, only observed in areas of severe piecemeal necrosis--interdigitating reticulum cells (IDRCs) and dendritic reticulum cells (DRCs). IDRCs are typical components of T-cell regions in lymphoid organs. Cells with the characteristics of IDRCs were found in severe piecemeal necrosis at the periphery of portal tracts and in periportal areas. This suggests that areas of periportal piecemeal necrosis are analogous to the T-cell regions of lymphoid organs during immune reactions. DRCs are typical components of B-cell regions in lymphoid organs. Cells with the characteristics of DRCs were found in the central parts of portal tracts with follicle-like aggregations of lymphocytes, as seen in some cases with pronounced piecemeal necrosis. This finding suggest that follicle-like lymphocytic aggregates in portal tracts are analogous to the B-cell regions of lymphoid organs during immune reactions. A mesenchymal origin of DRCs is suggested. The finding of IDRCs and DRCs in severe piecemeal necrosis emphasizes the fundamental similarity of immune reactions in the liver to those in lymphoid organs. These data are discussed in relation to immunological findings in chronic active hepatitis.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 69%

Interdigitating and dendritic reticulum cells in chronic active hepatitis

Bardadin

Desmet

1984

Histopathology

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“…The organisms attach to the luminal surface of the airway epithelium of rats and mice [12] and are not cleared from the airways despite strong cellular and humoral immune responses [11,[13][14][15]. The ongoing stimulus causes an influx of mononuclear cells, including DC, macrophages, and lymphocytes [15][16][17][18]. The development of mucosal lymphoid tissue is a prominent part of the remodeling of the airway mucosa, and is accompanied by epithelial cell and mucous gland hyperplasia, fibrosis, angiogenesis, and increased sensitivity of the newly formed blood vessels to the neuropeptide substance P [13,14,19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Although some of these changes may occur after viral infection [20,21], M. pulmonis infection is unusual in that it causes life-long disease and, if untreated, can result in severe remodeling of the airway mucosa [22]. The role of DC and other MHC class II expressing cells in these changes is unknown [16,17], but is of interest because of the rapid cellular response after infection and the strong immunological component of mycoplasmal airway disease.…”

Section: Introductionmentioning

confidence: 99%

Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection

Umemoto

Brokaw

Dupuis

et al. 2002

Cellular Immunology

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Mycoplasma pulmonis infection in rodents causes a chronic inflammatory airway disease with a strong immunological component, leading to mucosal remodeling and angiogenesis. We sought to determine the effect of this infection on the shape and number of dendritic cells and other major histocompatibility complex (MHC) class II expressing cells in the airway mucosa of Wistar rats. Changes in the shape of subepithelial OX6 (anti-MHC class II)-immunoreactive cells were evident in the tracheal mucosa 2 days after intranasal inoculation with M. pulmonis. By 1 week, the shape of the cells had changed from stellate to rounded (mean shape index increased from 0.42 to 0.77). The number of OX6-positive cells was increased 6-fold at 1 week and 16-fold at 4 weeks. Coincident with these changes, many columnar epithelial cells developed OX6 immunoreactivity, which was still present at 4 weeks. We conclude that M. pulmonis infection creates a potent immunologic stimulus that augments and transforms the OX6-immunoreactive cell population in the airways by changing the functional state of airway dendritic cells, initiating an influx of MHC class II expressing cells, and activating expression of MHC class II molecules by airway epithelial cells.

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“…Thus, bidirectional signaling mechanisms between FDCs and B cells are critical for establishment of a functional follicular structure. Furthermore, FDC-B cell interactions may play a critical role in organizing the follicle-like structures observed in multiple nonlymphoid tissues during chronic immune reactions (41)(42)(43)(44)(45)(46)(47).…”

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confidence: 99%

FDC-SP, a Novel Secreted Protein Expressed by Follicular Dendritic Cells

Marshall

Draves

et al. 2002

The Journal of Immunology

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To define better the molecular basis for follicular dendritic cell (FDC) function, we used PCR-based cDNA subtraction to identify genes specifically expressed in primary FDC isolated from human tonsils. In this work we report the discovery of a novel gene encoding a small secreted protein, which we term FDC-SP (FDC secreted protein). The FDC-SP gene lies on chromosome 4q13 adjacent to clusters of proline-rich salivary peptides and C-X-C chemokines. Human and mouse FDC-SP proteins are structurally unique and contain a conserved N-terminal charged region adjacent to the leader peptide. FDC-SP has a very restricted tissue distribution and is expressed by activated FDCs from tonsils and TNF-α-activated FDC-like cell lines, but not by B cell lines, primary germinal center B cells, or anti-CD40 plus IL-4-activated B cells. Strikingly, FDC-SP is highly expressed in germinal center light zone, a pattern consistent with expression by FDC. In addition, FDC-SP is expressed in leukocyte-infiltrated tonsil crypts and by LPS- or Staphylococcus aureus Cowan strain 1-activated leukocytes, suggesting that FDC-SP can also be produced in response to innate immunity signals. We provide evidence that FDC-SP is posttranslationally modified and secreted and can bind to the surface of B lymphoma cells, but not T lymphoma cells, consistent with a function as a secreted mediator acting upon B cells. Furthermore, we find that binding of FDC-SP to primary human B cells is markedly enhanced upon activation with the T-dependent activation signals such as anti-CD40 plus IL-4. Together our data identify FDC-SP as a unique secreted peptide with a distinctive expression pattern within the immune system and the ability to specifically bind to activated B cells.

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The Development of Extranodal Lymphoid Follicles in Experimental Bronchopneumonia

Cited by 6 publications

References 15 publications

Interdigitating and dendritic reticulum cells in chronic active hepatitis

Interdigitating and dendritic reticulum cells in chronic active hepatitis

Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection

FDC-SP, a Novel Secreted Protein Expressed by Follicular Dendritic Cells

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