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Extranodal formation of lymphoid follicles was morphologically studied in experimental bronchopneumonia. Control gnotobiotic mice had no peribronchial lymphoid follicles and only lymphatic vessels were traced from the terminal bronchiolar region toward larger bronchi. During the week after intranasal inoculation of mycoplasma pulmonis, lymphoid follicles developed in the terminal portion of the lymphatics by the accumulation of small lymphocytes. A loose network of mesenchymal cells and early infiltration of macrophages, following stromal edema, seemed to play an important role in the early accumulation of lymphocytes. Blastic transformation was seen frequently in the center of the accumulated lymphocytes. Two weeks after inoculation plasma cells emerged conspicuously in the periphery of the lymphoid follicles, and the acute phase of bronchopneumonia began to subside. Typical germinal centers with tingible body macrophages and dendritic reticulum cells developed when the bronchitis perisisted in a chronical manner. ACTA PATH. JAP. 29: 533–543, 1979.

Fifty-two cases of non-Hodgkin's lymphomas were studied with enzyme histochemical methods. Forty-four cases of these were also investigated for surface markers with immunological techniques, and results of histochemical, routine histological and immunological observations were correlated. Twenty-one of 27 B-cell lymphomas showed prominent ATPase activity, while all 13 T-cell lymphomas, except one case, did not show such activity. Nodular lymphomas, though of B-cell nature, were often negative for ATPase and it remained negative after diffuse evolution in some. Four of 7 AlPase positive lymphomas were of B-cell origin. Dot-like localized AcPase and /3-glucuronidase activity characterized T-cell lymphomas while 5 T-cell PDL, including lymphoblastic type with double markers, showed localized esterase activity. Enzyme histochemical characteristics of lymphomas were fairly honest reflection of those of various functional units in the normal lymph nodes. Enzyme histochemical methods appeared to be a useful tool for the study of lymphomas. ACTA PATH. JAP. 29: 739-753, 1979.

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