The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4<i>H</i>-1,2,4-triazol-3-yl)thio) acetate substance

Shcherbyna, R. О.; Парченко, В. В.; Varynskyi, B. O.; Kaplaushenko, A. G.

doi:10.2478/cipms-2019-0001

Cited by 11 publications

(6 citation statements)

References 13 publications

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“…Most scientists are trying to find just that substance based on heterocyclic compounds. A rather interesting heterocyclic compound, on the basis of which a huge number of new biologically active substances has already been synthesized, is the nucleus of 1,2,4-triazole [5][6][7][8]. The new compounds 1,2,4-triazole derivatives have a variety of designs and structures.…”

Section: Introductionmentioning

confidence: 99%

Microwave Synthesis of 3- And 4-Substituted-5-((3-Phenylpropyl)thio)-4h-1,2,4-Triazoles

Сафонов¹,

Nevmyvaka²,

Панасенко³

et al. 2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective:The purpose of this work was to synthesize 3-and 4-substituted-5-((3-phenylpropyl)thio) 4H-1,2,4-triazoles by the Milestone Flexi Wave microwave synthesis system and choose the best method of synthesis.Material and Method: The initial compounds 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol (1) and 5-(2-bromophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol (3) were synthesized at the Department of Natural Sciences for Foreign Students and Toxicological Chemistry of the Zaporizhzhya State Medical University (Ukraine). Milestone Flexi Wave microwave synthesis system was used to synthesize 3-and 4substituted-5-((3-phenylpropyl) thio)-4H-1,2,4-triazoles. The elemental analysis of synthesized compounds was established by the universal analyzer Elementar Vario L cube (CHNS). The 1H spectra (at 400 MHz) were recorded in DMSO-d6 on a Varian MR-400 spectrometer and analyzed with ADVASP™ Analyzer program. The gas chromatograph Agilent 7890B with a 5977B mass spectrometry detector (US) was used to define the completeness of the reactions and the individuality of the resulting compounds.Result and Discussion: The reaction was carried out in i-propanol medium and an equivalent amount of sodium hydroxide. (3-Bromopropyl)benzene was added to starting substances 1 and 3. To study the completeness of the reaction, different reaction times were used. Conditions such as temperature, microwave radiation, pressure were unchanged. The temperature of the reaction mixture was kept at 1650C, pressure 12.2 bar, MW ≈ 540 W. The reaction time was set at 15 minutes, 30 minutes, and 45 minutes. The most effective reaction time for obtaining 3-(thiophen-2-ylmethyl)-4-amino-5-((3-phenylpropyl)thio)-4H-1,2,4-triazole ( 2) is

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Section: Introductionmentioning

confidence: 99%

Microwave Synthesis of 3- And 4-Substituted-5-((3-Phenylpropyl)thio)-4h-1,2,4-Triazoles

Сафонов¹,

Nevmyvaka²,

Панасенко³

et al. 2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…Researchers from Ukraine are also looking for promising pharmacophores among 1,2,4-triazole derivatives. This is confirmed by articles [1][2][3][4][5][6][7][8][9][10]. Scientists are engaged in the synthesis [1][2][3][4][5][6], study of biological [1,2,5] action and analysis [7][8][9][10] of synthesized compounds based on 1,2,4-triazole nucleus.…”

Section: Introductionmentioning

confidence: 89%

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

et al. 2022

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The authors are not native speakers of Turkish The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. The search material was selected over the past decade with the highest number of citations at the time of literature analysis.

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“…After analyzing a number of scientific studies of scientists , we can conclude that studies of 1,2,4-triazole derivatives occupy an important place in the Ukrainian pharmaceutical industry [27][28][29][30][31][32]. The articles show that scientists have a fairly broad approach to the modification of 1,2,4-triazole heterocycle [27][28][29][30]. Aspects of studies of the biological action of 1,2,4-triazole derivatives are also covered.…”

Section: Figure 15mentioning

confidence: 99%

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

SAMELİUK¹,

Kaplaushenko²,

Zedan³

2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: Development of methods for the synthesis, studies of chemical, physico-chemical and biological properties of 1,2,4-triazole derivatives, in particular compounds with heterocyclic scaffolds and complex compounds as potential biologically active substances.Result and Discussion: In this review, 40 scientific papers reporting the properties of 1,2,4-triazole derivatives were evaluated. Each class of compounds described in the review was reported with the prospect of forming the direction for further research.Because of there is no enough studies about biological action of 1,2,4-triazole derivatives in human, it encourages further research.

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The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio) acetate substance

Cited by 11 publications

References 13 publications

Microwave Synthesis of 3- And 4-Substituted-5-((3-Phenylpropyl)thio)-4h-1,2,4-Triazoles

Microwave Synthesis of 3- And 4-Substituted-5-((3-Phenylpropyl)thio)-4h-1,2,4-Triazoles

Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

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