2019
DOI: 10.1080/14760584.2019.1651649
|View full text |Cite
|
Sign up to set email alerts
|

The development of inovirus-associated vector vaccines using phage-display technologies

Abstract: Introduction: Inovirus-associated vectors (IAVs) are derived from bacterial filamentous viruses (phages). As vaccine carriers, they have elicited both cellular and humoral responses against a variety of pathogens causing infectious diseases and other non-infectious diseases. By displaying specific antigen epitopes or proteins on their coat proteins, IAVs have merited much study, as their unique abilities are exploited for widespread vaccine development. Areas covered: The architectural traits of filamentous vi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
11
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(11 citation statements)
references
References 109 publications
0
11
0
Order By: Relevance
“…During replication, a characteristic feature is that they do not lyse the host (see Hay and Lithgow, 2019 for a recent review). While filamentous phages are known to infect a wide variety of bacterial species ( Roux et al, 2019 ), most of the work utilizing these phages has been based on those that infect E. coli (see Stern et al, 2019 for a recent review). This is largely based on the historical role of E. coli as a model organism for studying bacteria.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…During replication, a characteristic feature is that they do not lyse the host (see Hay and Lithgow, 2019 for a recent review). While filamentous phages are known to infect a wide variety of bacterial species ( Roux et al, 2019 ), most of the work utilizing these phages has been based on those that infect E. coli (see Stern et al, 2019 for a recent review). This is largely based on the historical role of E. coli as a model organism for studying bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…Phage DNA vaccines contain an expression cassette of antigens or mimetics in the phage genome ( González-Mora et al, 2020 ). Phage display vaccines consist of phages that display peptides or proteins fused to phage coat proteins with different peptides or proteins that are expressed as a single protein unit presented on the surface of the phage particle ( Stern et al, 2019 ). The third type of vaccine is a combination of the two types mentioned earlier.…”
Section: Introductionmentioning
confidence: 99%
“…The phage display technology involves cloning a gene encoding a foreign protein/peptide to a specific site in the phage gene encoding one of the phage coat proteins (i.e., major or minor) and the production of a coat fusion protein with an exogenous sequence when infecting eukaryotic cells. Such a system offers the possibility of exposing the foreign antigen based on each copy of the target capsid protein as well as generating mosaic viruses in which the given capsid proteins present a mix of wild-type and recombinant proteins with the desired oligopeptide [ 18 , 19 , 71 ].…”
Section: Phages As a Platform For Developing Vaccinesmentioning
confidence: 99%
“…A huge number of previous studies have utilized filamentous bacteriophages, a promising class of nanomaterials, as immunogenic carriers for inducing immune responses against peptides or proteins displayed on their surface [ 1 – 7 ]. Filamentous bacteriophage possesses undoubted superiorities like thermodynamic stability, high biocompatibility, low toxicity, and high antigen density capacity, which make them favorable for vaccine delivery applications [ 8 , 9 ]. Unmethylated CpG motifs of the bacteriophage genome act as immunostimulatory agents, which subsequently increase immunity [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%