The development of nanofiber tubes based on nanocomposites of polyvinylpyrrolidone incorporated gold nanoparticles as scaffolds for neuroscience application in axons

Abstract

In this report, nanofiber-based tubes as scaffolds for potential neuroscience application in the axon were fabricated by polyvinylpyrrolidone incorporated with gold nanoparticles (PVP/Au) in five different diameters via electrospinning. The objective of the study was to analyze the capacity of nanofiber-based tubes for potential voltage and the ability to form tubes of 0.2, 0.5, 1.0, 1.5 and 2.00 mm diameter as the scaffold. The capacity for potential voltage showed that PVP/Au is a well-blended material for suitable potential voltage. The morphology of nanofiber-based tubes was examined by scanning electron microscopy and transmission electron microscopy, which showed the good structural stability and good dispersion of Au nanoparticles in the nanofibers. Energy-dispersive X-ray spectroscopy and Fourier transform infrared spectra showed the presence of the Au component in PVP/Au and characteristic peaks of PVP and Au in the spectra, respectively. A wide-angle X-ray diffraction study showed that crystallinity was increased by the incorporation of Au in the PVP solution. The study of stress and strain behavior showed that when the diameter of the tubes was increased, the tensile strength of the tube was decreased but the bending behavior of the tubes was good and suitable for the axon. So, the nanofiber-based tube having a diameter of 0.2 mm made from PVP/Au is the better substrate for further in vivo or in vitro investigation, which will make this material more useful for tissue engineering.

<p>Antibacterial properties of in situ and surface functionalized impregnation of silver sulfadiazine in polyacrylonitrile nanofiber mats</p>

“…Nanofibers are important part of biomedical technology, as 60% of the total nanofiber production is specifically used in biomedical applications, such as in tumor therapy, 7 wound dressing, drug delivery, self-healing of wounds, or implants. [8][9][10][11] Silver, incorporated with natural or synthetic polymers, has been used as an effective antibacterial agent since decades. Silver has potential applications in health care, especially in the form of nanoparticles.…”

“…Natural and synthetic fibers have been electrospun either in single form or blends of different types of polymers to obtain desired features. 9,[33][34][35][36][37][38][39] Figure 1 briefly illustrates the process of electrospinning.…”

Application of Nanowires for Retinal Regeneration

“…Figure 5. The confocal microscopy image of seeded retinal ganglion cells into the random polypyrrole/graphene/poly (lactic-co-glycolic acid) nanofibers (a), polypyrrole/graphene nanofibers (b), the aligned polypyrrole/ graphene/poly (lactic-co-glycolic acid) nanofibers (c), the SEM mapping of loaded gold nanoparticles into the polyvinylpyrrolidone nanofiber (d) and the energy-dispersive X-ray for loaded gold nanoparticles into the polyvinylpyrrolidone nanofibers (e) [24,26].…”

“…supplied into the aligned nanofiber [26] and how nanofibers can simulate the extracellular matrixwith loading the gold nanoparticles into the nanofibers which done by our team [24].…”

“…Therefore, the electrospun nanofibers with a high ratio of surface-to-volume, tunable porosity, and similarity to natural EMC show the ability to modify the surface functions with different structures for a wide range of tissue regeneration [23]. Nanofibers have emerged as a potential to simulate the ECM in many tissues such as bone [10], nerves [24], and various techniques have been employed to fabricate the nanofibers with excellent properties [25].…”