The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews

Whiting, Penny; Rutjes, Anne W S; Reitsma, Johannes B.; Bossuyt, Patrick M.; Kleijnen, Jos

doi:10.1186/1471-2288-3-25

Cited by 3,191 publications

(2,469 citation statements)

References 14 publications

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“…The methodological quality of all studies was evaluated by QUADAS, which is a tested tool (Table 1; Appendix 2 contains an operationalization of the items) [65]. These items cover the most significant forms of bias in diagnostic research, such as, spectrum bias, disease progression bias, verification bias, review bias, and the potential bias associated with subject withdrawal, as well as aspects of external validity.…”

Section: Assessment Of Methodsological Qualitymentioning

confidence: 99%

A systematic review of the diagnostic accuracy of provocative tests of the neck for diagnosing cervical radiculopathy

et al. 2006

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Clinical provocative tests of the neck, which position the neck and arm inorder to aggravate or relieve arm symptoms, are commonly used in clinical practice in patients with a suspected cervical radiculopathy. Their diagnostic accuracy, however, has never been examined in a systematic review. A comprehensive search was conducted in order to identify all possible studies fulfilling the inclusion criteria. A study was included if: (1) any provocative test of the neck for diagnosing cervical radiculopathy was identified; (2) any reference standard was used; (3) sensitivity and specificity were reported or could be (re-)calculated; and, (4) the publication was a full report. Two reviewers independently selected studies, and assessed methodological quality. Only six studies met the inclusion criteria, which evaluated five provocative tests. In general, Spurling's test demonstrated low to moderate sensitivity and high specificity, as did traction/neck distraction, and Valsalva's maneuver. The upper limb tension test (ULTT) demonstrated high sensitivity and low specificity, while the shoulder abduction test demonstrated low to moderate sensitivity and moderate to high specificity. Common methodological flaws included lack of an optimal reference standard, disease progression bias, spectrum bias, and review bias. Limitations include few primary studies, substantial heterogeneity, and numerous methodological flaws among the studies; therefore, a meta-analysis was not conducted. This review suggests that, when consistent with the history and other physical findings, a positive Spurling's, traction/neck distraction, and Valsalva's might be indicative of a cervical radiculopathy, while a negative ULTT might be used to rule it out. However, the lack of evidence precludes any firm conclusions regarding their diagnostic value, especially when used in primary care. More high quality studies are necessary in order to resolve this issue.

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Section: Assessment Of Methodsological Qualitymentioning

confidence: 99%

A systematic review of the diagnostic accuracy of provocative tests of the neck for diagnosing cervical radiculopathy

et al. 2006

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“…4 Since then, different scoring systems have been developed to assess fecal loading on an abdominal radiograph. 5,6 On the basis of the same assumption, assessment of stool retention and size of rectum and colon are measured with rectal ultrasound scanning.…”

Section: (J Pediatr 2012;161:44-50)mentioning

confidence: 99%

Value of Abdominal Radiography, Colonic Transit Time, and Rectal Ultrasound Scanning in the Diagnosis of Idiopathic Constipation in Children: A Systematic Review

Berger

Tabbers

Kurver

et al. 2012

The Journal of Pediatrics

112

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“…We assessed the quality of the studies by using criteria selected from the QUADAS checklist for assessment of quality of diagnostic studies. 4 …”

Section: Data Abstraction and Quality Assessmentmentioning

confidence: 99%

Performance of tPSA and f/tPSA for prostate cancer in Chinese. A systematic review and meta-analysis

Wang

Sun

Pan

et al. 2006

Prostate Cancer Prostatic Dis

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Performing a systematic review and meta-analysis to evaluate the diagnostic performance of the total prostate-specific antigen (tPSA) tests for diagnosis of prostate cancer among Chinese. Literatures related to diagnosis of prostate cancer by tPSA and the ratio of free to total PSA (f/tPSA) being retrieved in five electronic databases. Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio (DOR) were pooled using random effects models. Summary receiver operating characteristic curves (SROC) used to summarize overall test performance. In total 10 studies meting the inclusion criteria, 2256 patients were included. Among them 423 were patients of prostate cancer compared to 1833 were patients of benign prostate hyperplasia (BPH). The pooled sensitivity and specificity of tPSA44.0 ng/ml, tPSA410.0 ng/ml and f/tPSAo0.15 as threshold for the diagnosis of prostate cancer were heterogeneity. The areas under SROC (AUC) were 80, 85 and 87%, respectively (Po0.05). The pooled DOR were 8.44(95%CI: 4.45B16.00), 9.94(95%CI: 4.15B23.77) and 13.75(95%CI: 6.35B29.76), respectively (Po0.05). v 2 test used for testing the heterogeneity. tPSA and f/tPSA made an important performance for diagnosis of prostate cancer in decade among Chinese. The use of f/tPSAo0.15 as threshold maintain a high prognostic accuracy for prostate cancer.

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The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews

Cited by 3,191 publications

References 14 publications

A systematic review of the diagnostic accuracy of provocative tests of the neck for diagnosing cervical radiculopathy

A systematic review of the diagnostic accuracy of provocative tests of the neck for diagnosing cervical radiculopathy

Value of Abdominal Radiography, Colonic Transit Time, and Rectal Ultrasound Scanning in the Diagnosis of Idiopathic Constipation in Children: A Systematic Review

Performance of tPSA and f/tPSA for prostate cancer in Chinese. A systematic review and meta-analysis

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