The diagnostic dilemma of primary central nervous system melanoma

Wadasadawala, Tabassum; Trivedi, Swati; Gupta, Tejpal; Epari, Sreedhar; Jalali, Rakesh

doi:10.1016/j.jocn.2009.12.020

Cited by 67 publications

(75 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9,14,19,20 Amelanotic melanoma and melanoma without hemorrhage are iso-or hypointense on T1WI and moderately hyperintense on T2WI. [21][22][23] Isiklar et al 24 reviewed the MR images of 30 patients with intracerebral melanoma and sorted these into 4 groups: melanotic pattern (hyperintense on T1WI, In case 1, the sagittal (A ) and axial (D ) contrast-enhanced T1WI and morphologic changes (G, HE original magnification ϫ400) of the lesion are seen. In case 2, the sagittal (B ) and axial (E ) contrast-enhanced T1WI sequences and morphologic changes (H, HE original magnification ϫ200) of the lesion are seen.…”

Section: Discussionmentioning

confidence: 99%

“…Wadasadawala et al 22 considered the following aspects useful for the differential diagnosis of MM: 1) Location: Pigmented meningioma is located in the extra-axial area; melanotic schwannoma is located in the cerebellopontine angle; MM and primary melanoma are often located in the high cervical cord or perimedullary area, whereas metastatic melanoma is located in the supratentorial or gray-white matter junction. 2) Number: The lesion of pigmented meningioma, MM, or primary melanoma is often single, while metastatic melanoma is multiple.…”

Section: Discussionmentioning

confidence: 99%

“…3) Hemorrhage: The pigmented meningioma and melanotic schwannoma do not have a hemorrhagic focus, while MM and primary and metastatic melanoma often have it. 22 4) Dural involvement: Dural involvement and the "dural tail" sign are often observed in meningioma, MM, or meningeal melanocytosis, but metastatic melanoma seldom presents dural involvement.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

SUMMARY:Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.ABBREVIATIONS: EMA ϭ epithelial membrane antigen; HMB-45 ϭ human melanoma black-45; IHC ϭ immunohistochemistry; MM ϭ meningeal melanocytoma P rimary melanocytic neoplasms of the CNS are lesions arising from melanocytes of the leptomeninges. Melanocytes are melanin-producing cells that derive from the neural crest during embryogenesis and then migrate to the skin, mucous membranes, and CNS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…He described the primary CNS melanoma when there are (1) no malignant melanoma outside CNS, (2) absences of this lesion in other part of CNS, and (3) histological confirmations of melanoma [8]. Since then, no other criteria have been developed [18] probably because the low incidences of primary CNS melanoma. In presented case, the patient had these three points and he was diagnosed of primary cerebral melanoma in unusual location after these points were checked.…”

Section: Discussionmentioning

confidence: 99%

Primary cerebral malignant melanoma in insular region with extracranial metastasis: case report and review literature

et al. 2016

View full text Add to dashboard Cite

BackgroundPrimary brain melanomas are very infrequent and metastasis outside central nervous system very uncommon. There are some cases in the literature about primary melanoma in the temporal lobe; nevertheless, the insular location has never been described.Case presentationThe patient presented as left insular intraparenchymal hematoma with multiple bleedings. Complementary tests did not show any tumoral nor vascular pattern in relation with these bleedings. A complete surgical resection was performed, and the diagnosis of malignant melanoma, with BRAF mutation, was obtained after histology exam. Extension studies were negative for skin or mucous melanoma. 18F-FDG PET/CT was performed and a metastatic lymph node was found. The diagnosis was primary brain melanoma with extracerebral metastasis. Dabrafenib 150 mg/12 h was the only chemotherapy during 5 months. After that, Trametinib 2 mg/24 h was added to the treatment. Eighteen months after surgery, the patient is independent, with stable situation, and without new metastasis.ConclusionsAlthough malignant melanomas have poor prognosis, total surgical resection and new therapies are increasing the overall survival and improving quality of life. In a patient with suspected brain melanoma, in spite of having extracerebral metastasis, aggressive treatment may be considered.

show abstract

“…Metastatic intracranial malignant melanoma (MIMM) from cutaneous malignant melanoma (CMM) is a frequent occurrence. PIMM is difficult to diagnose because PIMM and MIMM are similar in radiological and pathological appearance6,15). On the other hand, extracranial metastasis of PIMM is extremely rare.…”

Section: Introductionmentioning

confidence: 99%

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Hirota

Yoshimura

Kubo

et al. 2017

J Korean Neurosurg Soc

View full text Add to dashboard Cite

We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases. She died at 13 months after surgery. Although extracranial metastases of PIMM are extremely rare, we should carefully follow up extracranial metastases together with intracranial ones, especially by FDG-PET/CT, even at an early asymptomatic stage.

show abstract

The diagnostic dilemma of primary central nervous system melanoma

Cited by 67 publications

References 10 publications

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Primary cerebral malignant melanoma in insular region with extracranial metastasis: case report and review literature

Primary Intracranial Malignant Melanoma with Extracranial Metastasis

Contact Info

Product

Resources

About