The diagnostic role and mechanistic functions of exosomal lncRNAs in prostate cancer

Zhou, Hangsheng; Wan, Hongyuan; Feng, Yanyan; Zhu, Lijie; Mi, Yuanyuan

doi:10.1007/s12094-022-02982-w

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…In addition, immune cells infiltrating into TME mainly include tumor-associated macrophages (TAMs), neutrophils, NK cells, and T and B cell subsets [48]. These immune cells could interact with tumor cells to exert pro-or anti-tumor effects, which may be attributed to exosomal lncRNAs mediated immune regulation in TME [49,50]. Although the effects of exosomes or lncRNAs alone in cancer immunity are still under investigation, the immunomodulation effects of exosome-derived lncRNAs in cancer also need clarification.…”

Section: Introductionmentioning

confidence: 99%

Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential

Zhang

Yan

Peng

et al. 2022

Cancers

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Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological and pathological processes. Interestingly, a plethora of studies emphasized the mediating role of exosomes in the bidirectional communication between donor and recipient cells. Among the various cargoes of exosomes, long non-coding RNAs (lncRNAs) have been identified as crucial regulators between cancer cells and immune cells in the tumor microenvironment (TME) that can interfere with innate and adaptive immune responses to affect the therapeutic efficiency. Recently, a few major studies have focused on the exosomal lncRNA-mediated interaction between cancer cells and immune cells infiltrated into TME. Nevertheless, a dearth of studies pertains to the immune regulating role of exosomal lncRNAs in cancer and is still in the early stages. Comprehensive mechanisms of exosomal lncRNAs in tumor immunity are not well understood. Herein, we provide an overview of the immunomodulatory function of exosomal lncRNAs in cancer and treatment resistance. In addition, we also summarize the potential therapeutic strategies toward exosomal lncRNAs in TME.

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Section: Introductionmentioning

confidence: 99%