The Diagnostic Value of 99mTc-HMPAO-Labelled White Blood Cell Scintigraphy and 18F-FDG PET/CT in Cardiac Device-Related Infective Endocarditis—A Systematic Review

Holcman, Katarzyna; Rubiś, Paweł; Stępień, Agnieszka; Graczyk, Katarzyna; Podolec, Piotr; Kostkiewicz, Magdalena

doi:10.3390/jpm11101016

Cited by 13 publications

(15 citation statements)

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“…The diagnostic properties of 99m Tc-HMPAO-SPECT/CT in cardiac device-related infections were evaluated in multiple studies [ 26 , 27 , 28 , 29 , 30 ]. It is characterized cumulatively by 60–93.7% sensitivity, 88–100% specificity, 84.6–93.9% negative predictive value (NPV), and 74–100% positive predictive value (PPV) [ 31 ]. Besides the extent of device involvement, the detected extracardiac inflammatory lesions were diagnosed as: extracardiac concomitant infection, initial sites of infection leading to CDRIE, or coexisting inflammatory lesions [ 31 ].…”

Section: 99m Tc-hmpao-spect/ctmentioning

confidence: 99%

Advances in Molecular Imaging in Infective Endocarditis

et al. 2023

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Infective endocarditis (IE) is a growing epidemiological challenge. Appropriate diagnosis remains difficult due to heterogenous etiopathogenesis and clinical presentation. The disease may be followed by increased mortality and numerous diverse complications. Developing molecular imaging modalities may provide additional insights into ongoing infection and support an accurate diagnosis. We present the current evidence for the diagnostic performance and indications for utilization in current guidelines of the hybrid modalities: single photon emission tomography with technetium99m-hexamethylpropyleneamine oxime–labeled autologous leukocytes (99mTc-HMPAO-SPECT/CT) along with positron emission tomography with fluorodeoxyglucose (18F-FDG PET/CT). The role of molecular imaging in IE diagnostic work-up has been constantly growing due to technical improvements and the increasing evidence supporting its added diagnostic and prognostic value. The various underlying molecular processes of 99mTc-HMPAO-SPECT/CT as well as 18F-FDG PET/CT translate to different imaging properties, which should be considered in clinical practice. Both techniques provide additional diagnostic value in the assessment of patients at risk of IE. Nuclear imaging should be considered in the IE diagnostic algorithm, not only for the insights gained into ongoing infection at a molecular level, but also for the determination of the optimal clinical therapeutic strategies.

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Section: 99m Tc-hmpao-spect/ctmentioning

confidence: 99%

Advances in Molecular Imaging in Infective Endocarditis

et al. 2023

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“…2022;5(2):18-34. DOI: 10.37174/2587-7593-2022-5-2- [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] При подозрении на воспалительные реакции необходимо собрать полный анамнез пациента, провести его физикальный осмотр, направить на выполнение анализов (общий и биохимический анализ крови) и только после этого проводить инструментальное дообследование. Многие современные методы, такие как КТ, МРТ, УЗИ, часто не способны обнаружить воспаление до появления морфологических изменений в тканях, тогда как радионуклидные методы диагностики способны визуализировать очаг воспаления на ранних стадиях за счет локальных физикохимических изменений.…”

Section: рефератunclassified

“…Оптимальное время регистрации сцинтиграфических изображений, получаемых при помощи лейкоцитов, меченных 111 In, составляет 24 ч после введения РФЛП, а при использовании в качестве радионуклидной метки 99m Тс -3 ч. Метод меченых лейкоцитов широко применяют для выявления острых воспалительных очагов любой локализации, за исключением патологии селезенки [26,27]. В России на сегодняшний день доступна только методика мечения лейкоцитов 99m Тс.…”

Section: ядерная медицинаunclassified

“…Меченые клетки после их введения быстро выводятся мочевыделительной системой с получением изображения почек и мочевого пузыря. Спустя 2-3 ч определяется физиологическое повышенное накопление РФЛП в желчном пузыре, а затем и кишечнике [26,31]. Распределение 99m Тс-ГМПАО в костном мозге, печени и селезенке аналогично распределению в них 111 In-оксина.…”

Section: лейкоциты меченные 99m Tc-гмпаоunclassified

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The Possibilities of Nuclear Medicine Methods in Inflammation Diagnosis

Svetlyakova¹,

Крылов²,

Рыжков

et al. 2022

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Modern nuclear medicine is a rapidly developing field that includes various non-invasive molecular imaging techniques with the ability to examine the whole body.Inflammation is a frequent complication in surgical and traumatological practices, which is a complex, local and general pathological process that occurs in the body in response to injury. Having arisen under the influence of a damaging factor, inflammation is characterized by the development of a dynamic complex of changes. However, the search for inflammation foci of inflammation by traditional diagnostic methods in some cases is difficult even with a detailed clinical picture. In this case, nuclear medicine, which is able to visualize pathological processes, including those with a pathological increase in metabolism, may be the best option for finding the affected area.A wide variety of radiopharmaceutical drugs makes it possible to determine the localization of the inflammatory focus in a short time and with high accuracy and makes nuclear imaging methods a priority for the early diagnosis of pathophysiological reactions.This paper presents a review of domestic and foreign literature on the use of specific and nonspecific radiopharmaceuticals in the diagnosis of inflammation. Own cases is also presented.

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“…Katarzyna Holcman and co-authors present a high-quality systematic review on the diagnostic value of 99 mTc-HMPAO-labelled white blood cell scintigraphy and 18F-FDG PET/CT in cardiac device-related infective endocarditis. This paper analyses all published data on scintigraphy and PET in the setting of cardiac device-related infective endocarditis [ 9 ]. Another review comes from an established group with a long record of studies in the field of aortic stenosis; in this paper, Joanna Natorska et al comment on current randomized trials investigating the medical treatment of aortic stenosis, including strategies based on lipid-lowering and antihypertensive therapies, phosphate and calcium metabolism, and novel therapeutic targets such as valvular oxidative stress, coagulation proteins, matrix metalloproteinases and the accumulation of advanced glycation end products [ 10 ].…”

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confidence: 99%