The diagnostic value of modified systemic ınflammation score in predicting post-operative outcomes of cutaneous melanoma patients who underwent ısolated limb perfusion

Abstract

Background In-transit metastasis is considered a locoregional disease in cutaneous melanoma (CM) patients. Isolated limb perfusion (ILP) is among the treatment options in selected cases. The aim of this study was to determine the success of pre- and post-perfusion mSIS values in predicting the potential complications and the prognosis of the disease by investigating the early and long-term results of mSIS values calculated before and after ILP in CM cases with in-transit metastases. Materials and methods Patients who underwent ILP within the period from 2014 to 2020 in our department were retrospectively scanned. A total of 20 patients were found to undergo ILP. The scores obtained from modified inflammation score (mSIS) were formulated according to albumin (Alb) and lymphocyte to monocyte ratio (LMR) scores. Results The mean follow-up time was 20.47 months. Complications requiring surgical intervention developed in three patients. According to the Wieberdink local toxicity classification, the majority (70%) of the patients were found to be grade II. Based on pre-perfusion mSIS values, 8 patients were classified as mSIS 0 while six patients were classified as mSIS 1 and 2. Based on post-perfusion mSIS values, 14 patients and one patient were classified as mSIS 2 (70%) and mSIS 0, respectively. Accordingly, univariate analysis showed that mSIS 1 and mSIS 2 were negative prognostic factors for mean survival in the pre-perfusion period (HR 0.162, 95% CI 0.036–0.729; p = 0.018 and HR: 0.223, 95% CI 0.049–1.019; p = 0.053) whereas albumin (Alb) and lymphocyte to monocyte ratio (LMR) were not independent prognostic factors for mean survival. Conclusion The mSIS values calculated in the pre-perfusion period can give an opinion about the OS of the patients whereas post-perfusion mSIS values may predict potential surgical complications and local toxicities.

Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules?

“…13 mSIS is also associated with prognosis of melanoma, lymphoma, breast cancer, and lung cancer. [16][17][18][19] Inflammation is considered to have a significant influence on the development and prognosis of cancer. Studies that claim a relationship between preoperative mSIS and malignancy have tried to explain this relationship.…”

“…Circulating monocytes, which are different from lymphocytes, develop into macrophages, accelerate the development of malignancy by encouraging tumor progression, angiogenesis, and metastasis. 13,[19][20][21][22] There are just a few research on the relationship between biochemical markers and malignancy in TN. Ataş et al concluded that there is a significant relationship between mSIS and malignancy and so it can be used as a marker for making surgical decisions in their 2 separate studies on indeterminate TN and persistent nondiagnostic TN.…”

The Prognostic Importance of the Systemic Inflammatory Index in Pathologies of the Larynx

“…24,25 mSIS is also associated with prognosis of melanoma, lymphoma, breast cancer, and lung cancer. [26][27][28][29] However, the value of mSIS, for predicting malignancy remains unclear. [30][31][32] Further studies evaluating the SII and mSIS together will help to understand the predictive effect.…”