M ost manifestations of cardiovascular disease are more common in men than in women. However, cardiovascular disease is the most common cause of death in women worldwide. 1 Coronary heart disease in women has a worse outcome than in men, and this has attracted considerable attention in recent years, with calls for more gender-specific research. 1,2 Abdominal aortic aneurysms (AAAs) also are less common in women than in men, and, as with coronary heart disease, there is evidence that women with AAA also have a worse prognosis. The present review addresses the epidemiology, development, natural history, management, and outcomes of AAA in women.
Prevalence and IncidenceWhen the definition of a maximum external diameter Ն3 cm is used, the prevalence of AAA is up to 6 times greater in men than in women. 3,4 In a community-based screening study of the older population, the prevalence of AAA was 1.3% in women compared with 7.6% in men. 4 Similarly, the ratio of men to women in surgical series is Ϸ5:1. 5-7 Because of the relatively low prevalence, women were excluded from the large trials of screening for AAA. 8 -10 The prevalence in women from families with a strong history of AAA may be as high as 8.3%, and these women should be offered screening. 11 Modeling studies have indicated that screening for AAA in women could be cost-effective because the rupture rate appears to be much higher in women than in men. 12 The incidence of AAA has continued to rise over the last 4 decades. [13][14][15][16] Initially, a similar pattern was seen in both genders, although the increase in mortality and admission rate has been become more marked in women. 15,16 Inspection of data derived from national (England and Wales) statistics shows that the annual number of hospital admissions for aneurysm rupture between 1997 and 2005 has declined by 2% to 3% per annum in men. 17 In women, although the total number of admissions for ruptured AAA is Ϸ40% of male admissions, there has been an increase of Ϸ0.5% per annum since 2005. The reasons for this are unknown. Population screening for AAA in men is not yet widespread in England and Wales and is unlikely to have made a major contribution to these trends. However, AAA appears to be a late event after smoking exposure, and these trends may reflect temporal changes in smoking prevalence. The rise of smoking in women occurred over the period 1950 to 1970, several decades after the widespread uptake of smoking by men. Since then, rates of cessation have been greater in men than in women. 18 The presence of an AAA is associated with aneurysms of the iliac, femoral, and popliteal arteries, but, compared with AAA, all of these have a higher incidence ratio in men versus women. 19 However, some aneurysms are found predominantly or equally in women, with splenic 20 and cerebral artery 21 aneurysms being respective examples.
Natural History: Expansion and RuptureThere is no good evidence to suggest that aneurysm growth rate is different in men and women. 22 Although a single small study suggested that ...