The diarrheal mechanism of mice with a high-fat diet in a fatigued state is associated with intestinal mucosa microbiota

Liu, Jing; Qiao, Bo; Deng, Na; Wu, Yi; Li, Dandan; Tan, Zhoujin

doi:10.1007/s13205-023-03491-5

Cited by 17 publications

(16 citation statements)

References 70 publications

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“…In the CMD group, mice stood on the multiple platform apparatus for 4 h per day for 14 consecutive days, and intragastric lard was administered twice daily from the eighth to the fourteenth day. [ 15,17,18 ] Before the gavage of lard, the study used hot water to emulsify the lard into liquid. The CCN group was given sterile water twice a day for 7 days, starting on the eighth day of modeling.…”

Section: Methodsmentioning

confidence: 99%

“…[ 14 ] And the gut mucosal barrier injury and disturbance of gut mucosal microbiota might be involved in excessive fatigue and high‐fat diet‐induced diarrhea. [ 15 ] Nevertheless, the specific mechanism behind fatigue and HFD‐induced gastrointestinal diseases are mostly obscure. Consequently, we aim to elucidate the potential molecular interactions between gut microbiota's metabolic process and gastrointestinal diseases by establishing a mouse model of an HFD in a fatigued state and combining gut microbiota characteristics and SCFAs.…”

Section: Introductionmentioning

confidence: 99%

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Association of Short‐Chain Fatty Acids with Gut Microbiota and Lipid Metabolism in Mice with Diarrhea Induced by High‐Fat Diet in a Fatigued State

Qiao,

Liu,

Peng

et al. 2023

Molecular Nutrition Food Res

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ScopePreliminary research finds that a high‐fat diet (HFD) in a fatigued state triggers diarrhea, but the exact mechanism has not been clarified. To address concerns about the pathogenesis of diarrhea, the study evaluates the composition and metabolomics of the gut microbiota.Methods and resultsThe study uses the multiple platform apparatus device to induce fatigue in mice, combined with intragastric administration of lard‐caused diarrhea. Subsequently, the characteristics and interaction relationship of gut microbiota, short‐chain fatty acids (SCFAs), inflammatory biomarkers, brain‐gut peptides, and lipid metabolism are analyzed at the end of the experiment. HFD in a fatigued state results in a significant increase in interleukin‐17, interleukin‐6, cholecystokinin, somatostatin, and malondialdehyde content in mice (p < 0.05), along with a substantial decrease in high‐density lipoprotein (p < 0.05). Additionally, an HFD in a fatigued state causes changes in the structure and composition of the gut microbiota, with Lactobacillus murinus as its characteristic bacteria, and reduces the production of SCFAs.ConclusionsAn HFD in a fatigued state triggers diarrhea, possibly associated with gut content microbiota dysbiosis, SCFAs deprivation, increased inflammation, and dysregulated lipid metabolism.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Short‐Chain Fatty Acids with Gut Microbiota and Lipid Metabolism in Mice with Diarrhea Induced by High‐Fat Diet in a Fatigued State

Qiao,

Liu,

Peng

et al. 2023

Molecular Nutrition Food Res

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“…Model interventions based on the literature [16][17][18][19] and preexperiment: mice in the CSD and CSLD groups stood on the multiple-platform apparatus for four h per day for 14 consecu-tive days. The CCN and CSD groups were not given any intervention from the first to the seventh day.…”

Section: Managementmentioning

confidence: 99%

Gut content microbiota dysbiosis and dysregulated lipid metabolism in diarrhea caused by high-fat diet in a fatigued state

et al. 2023

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“…The changes in intestinal flora increase intestinal permeability and promote LPS to enter the blood to activate the NF-kB signal pathway, which leads to chronic inflammation, endotoxemia, and increased fat accumulation, and ultimately leads to metabolic syndrome and obesity (73). The high-fat diet could induce the interactions between Thermoactinomyces, Staphylococcus, and intestinal inflammation (74).…”

Section: The Chronic Mild Inflammatory Responsementioning

confidence: 99%

An overview of traditional Chinese medicine affecting gut microbiota in obesity

Tang

Wang

et al. 2023

Front. Endocrinol.

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Obesity, a chronic metabolic disease with a complex pathophysiology, is caused by several variables. High-fat diets lead to the disruption of the gut microbiota and impaired gut barrier function in obese people. The dysbiosis and its metabolites through the intestinal barrier lead to an imbalance in energy metabolism and inflammatory response, which eventually contributes to the development of chronic diseases such as diabetes, hypertension, and cardiovascular disease. Current medicines are therapeutic to obesity in the short term; however, they may bring significant physical and emotional problems to patients as major side effects. Therefore, it is urgent to explore new therapeutic methods that have definite efficacy, can be taken for a long time, and have mild adverse effects. Numerous studies have demonstrated that traditional Chinese medicine (TCM) can control the gut microbiota in a multi-targeted and comprehensive manner, thereby restoring flora homeostasis, repairing damaged intestinal mucosal barriers, and eventually curbing the development of obesity. The active ingredients and compounds of TCM can restore the normal physiological function of the intestinal mucosal barrier by regulating gut microbiota to regulate energy metabolism, inhibit fat accumulation, affect food appetite, and reduce intestinal mucosal inflammatory response, thereby effectively promoting weight loss and providing new strategies for obesity prevention and treatment. Although there are some studies on the regulation of gut microbiota by TCM to prevent and treat obesity, all of them have the disadvantage of being systematic and comprehensive. Therefore, this work comprehensively describes the molecular mechanism of obesity mediated by gut microbiota based on the research state of obesity, gut microbiota, and TCM. A comprehensive and systematic summary of TCM targeting the regulation of gut microbiota for the treatment of obesity should be conducted in order to provide new strategies and ideas for the treatment of obesity.

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The diarrheal mechanism of mice with a high-fat diet in a fatigued state is associated with intestinal mucosa microbiota

Cited by 17 publications

References 70 publications

Association of Short‐Chain Fatty Acids with Gut Microbiota and Lipid Metabolism in Mice with Diarrhea Induced by High‐Fat Diet in a Fatigued State

Association of Short‐Chain Fatty Acids with Gut Microbiota and Lipid Metabolism in Mice with Diarrhea Induced by High‐Fat Diet in a Fatigued State

Gut content microbiota dysbiosis and dysregulated lipid metabolism in diarrhea caused by high-fat diet in a fatigued state

An overview of traditional Chinese medicine affecting gut microbiota in obesity

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