The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes

Davidson, W. Sean; Cooke, Allison L; Swertfeger, Debi K.; Shah, Amy S.

doi:10.1007/s11883-021-00925-4

Cited by 25 publications

(26 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, HDL subspecies defined by the components of minor protein or lipid could exert diverse effects on the development of cardiovascular disease (44). While atheroprotective effects of HDL containing APOE or APOC1 were observed (45,46), APOC-III-containing HDL was associated with higher carotid intima-media thickness (47) and higher risk of CHD (48) in the general population.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, both high levels of cholesterol efflux capacity, antioxidant capacity, and anti-inflammatory capacity of HDL were associated with lower cardiovascular disease risk, while further studies are still needed to confirm these findings ( 43 ). However, HDL subspecies defined by the components of minor protein or lipid could exert diverse effects on the development of cardiovascular disease ( 44 ). While atheroprotective effects of HDL containing APOE or APOC1 were observed ( 45 , 46 ), APOC-III-containing HDL was associated with higher carotid intima-media thickness ( 47 ) and higher risk of CHD ( 48 ) in the general population.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases

Mao

Hu²,

Xia

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

ObjectiveGestational diabetes mellitus (GDM) has been linked to subsequent overall cardiovascular diseases. However, evidence on the associations of GDM with type-specific cardiovascular diseases is lacking, and findings on the potential impact of type 2 diabetes on the associations are not consistent. This study aimed to explore the associations between GDM and the risks of type-specific cardiovascular diseases.MethodsData were from 12,025 women (≥20 years) who had delivered at least one live birth in the National Health and Nutrition Examination Survey, 2007–2018. GDM history and type-specific cardiovascular diseases including coronary heart disease (CHD), heart failure and stroke were defined by self-report. We also combined our results with those from previously related publications on the associations between GDM and risks of type-specific cardiovascular diseases with a random-effect model.ResultsCompared with women without GDM, the multivariable-adjusted odds ratios (95% confidence intervals) were 1.82 (1.21–2.72) for CHD, 1.43 (0.80–2.53) for heart failure, and 1.19 (0.76–1.86) for stroke among women with a history of GDM. Type 2 diabetes was associated with 43.90, 67.44, and 63.16% of the excess odds of CHD, heart failure and stroke associated with GDM, respectively. Combining results from this study with those from previously related studies yielded odds ratios (95% confidence intervals) of 1.81 (1.60–2.05) for CHD (12 studies, 7,615,322 participants, I2= 72.6%), 1.66 (1.25–2.21) for heart failure (5 studies, 4,491,665 participants, I2= 88.6%), and 1.25 (1.07–1.46) for cerebrovascular disease (9 studies, 6,090,848 participants, I2= 77.8%).ConclusionsGDM showed stronger associations with coronary heart diseases and heart failure than cerebrovascular disease, and the excess risks are attributable, in part, to type 2 diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases

Mao

Hu²,

Xia

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…HDL also reduces tumor necrosis factor-α, a driver of calcification, in AV [ 26 ]. HDL particles also carry a vast proteome which may account for the spectrum of anti-inflammatory and antioxidant properties as cholesterol acceptors, and future studies should focus on these properties in relation to protection against AV calcification [ 44 ]. Estrogen may protect against the development of valvular calcification, which could account for delayed accumulation in women as compared to men.…”

Section: Discussionmentioning

confidence: 99%

Measures of high-density lipoprotein function in men and women with severe aortic stenosis

2022

View full text Add to dashboard Cite

Background Calcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis (AS). Sex-specific differences in aortic valve calcification (ACV) exist, with women having a lower burden of calcification than men as measured by computed tomography; however, the pathophysiological mechanism that leads to these differences remains unclear. Methods Using cultured human Tamm-Horsfall protein 1 (THP-1) macrophages and human aortic valve interstitial cells, the effects of high-density lipoprotein (HDL) particles isolated from the plasma of men and women with severe AS were studied for cholesterol efflux capacity (CEC). Results HDL-CEC was assessed in 46 patients with severe AS, n = 30 men, n = 16 women. ATP-Binding Cassette A1 (ABCA1)-mediated HDL-CEC was measured from human cultured THP-1 macrophages to plasma HDL samples. Women with severe AS had more ABCA1-mediated HDL-CEC, as compared to men (8.50 ± 3.90% cpm vs. 6.80 ± 1.50% cpm, P = 0.04). HDL pre-β1 and α-particles were higher in woman than in men by spectral density, (pre-β1 HDL, 20298.29 ± 1076.15 vs. 15,661.74 ± 789.00, P = 0.002, and α-HDL, 63006.35 ± 756.81 vs. 50,447.00 ± 546.52, P = 0.03). Lecithin-cholesterol acyltransferase conversion of free cholesterol into cholesteryl esters was higher in women than men (16.44 ± 9.11%/h vs. 12.00 ± 8.07%/h, P = 0.03). Conclusions Sex-specific changes in various parameters of HDL-CEC were found in patients with severe AS. Sex-based modifications in HDL functionality by HDL-CEC might account for the reduced burden of calcification in women vs. men with severe AS. Therefore, future studies should target sex-related pathways in AS to help to improve understanding and treatment of AS. Graphical abstract Sex specifc differences in AVC and differences associated with HDL function in men and women with severe AS. When compared to men, women had higher preβ-HDL and α-HDL migrating particles, higher cholesterol efflux to HDL, and higher lecithin cholesterol acyl transferase (LCAT) activity, possibly indicating that improved reverse cholesterol transport may be protective against worsened calcification.

show abstract

“…Many reports followed this initial observation including studies from Israel [9], the Framingham Study [10], and Sweden [11]. These initial clinical reports were rapidly followed by studies on distribution and composition of HDL subclasses, in particular evaluating conditions of extreme HDL reductions [12], as well as distribution of particles [13]. This last observation was followed by contrasting reports.…”

Section: Hdl and Prevention Of Cardiovascular Risk-development Of A C...mentioning

confidence: 99%

The Role of High-Density Lipoprotein Cholesterol in 2022

Sirtori

Corsini

Ruscica

2022

Curr Atheroscler Rep

View full text Add to dashboard Cite

Purpose of the Review High-density lipoproteins (HDL) are responsible for the transport in plasma of a large fraction of circulating lipids, in part from tissue mobilization. The evaluation of HDL-associated cholesterol (HDL-C) has provided a standard method for assessing cardiovascular (CV) risk, as supported by many contributions on the mechanism of this arterial benefit. The present review article will attempt to investigate novel findings on the role and mechanism of HDL in CV risk determination. Recent Findings The most recent research has been aimed to the understanding of how a raised functional capacity of HDL, rather than elevated levels per se, may be responsible for the postulated CV protection. Markedly elevated HDL-C levels appear instead to be associated to a raised coronary risk, indicative of a U-shaped relationship. Summary While HDL-C reduction is definitely related to a raised CV risk, HDL-C elevations may be linked to non-vascular diseases, such as age-related macular disease. The description of anti-inflammatory, anti-oxidative and anti-infectious properties has indicated potential newer areas for diagnostic and therapeutic approaches. In the last two decades inconclusive data have arisen from clinical trials attempting to increase HDL-C pharmacologically or by way of recombinant protein infusions (most frequently with the mutant A-I Milano); prevention of stent occlusion or heart failure treatment have shown instead significant promise. Targeted clinical studies are still ongoing.

show abstract

The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes

Cited by 25 publications

References 59 publications

Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases

Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases

Measures of high-density lipoprotein function in men and women with severe aortic stenosis

The Role of High-Density Lipoprotein Cholesterol in 2022

Contact Info

Product

Resources

About