The difference of social cognitive and neurocognitive performance between patients with schizophrenia at different stages and influencing factors

Chen, Sheng-Yun; Liu, Yaxi; Liu, Dennis; Zhang, Gui-Can; Wu, Xiaoli

doi:10.1016/j.scog.2021.100195

Cited by 9 publications

(13 citation statements)

References 48 publications

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“…Additionally, this study demonstrated that widespread cognitive impairments existed in schizophrenia patients with AVH in all seven cognitive domains of MCCB and agreed with the previously published studies, which reported that patients with schizophrenia had widespread cognitive deficits ( Schuepbach et al, 2002 ; Chen et al, 2021 ). Furthermore, we found that certain cognitive domains, such as verbal learning and visual learning, were improved after the rTMS treatment for patients.…”

Section: Discussionsupporting

confidence: 92%

rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

et al. 2021

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BackgroundLow-frequency transcranial magnetic stimulation (rTMS) over the left temporoparietal cortex reduces the auditory verbal hallucination (AVH) in schizophrenia. However, the underlying neural basis of the rTMS treatment effect for schizophrenia remains not well understood. This study investigates the rTMS induced brain functional and structural alternations and their associations with clinical as well as neurocognitive profiles in schizophrenia patients with AVH.MethodsThirty schizophrenia patients with AVH and thirty-three matched healthy controls were enrolled. The patients were administered by 15 days of 1 Hz rTMS delivering to the left temporoparietal junction (TPJ) area. Clinical symptoms and neurocognitive measurements were assessed at pre- and post-rTMS treatment. The functional (amplitude of low-frequency fluctuation, ALFF) and structural (gray matter volume, GMV) alternations were compared, and they were then used to related to the clinical and neurocognitive measurements after rTMS treatment.ResultsThe results showed that the positive symptoms, including AVH, were relieved, and certain neurocognitive measurements, including visual learning (VisLearn) and verbal learning (VerbLearn), were improved after the rTMS treatment in the patient group. Furthermore, the rTMS treatment induced brain functional and structural alternations in patients, such as enhanced ALFF in the left superior frontal gyrus and larger GMV in the right inferior temporal cortex. The baseline ALFF and GMV values in certain brain areas (e.g., the inferior parietal lobule and superior temporal gyrus) could be associated with the clinical symptoms (e.g., positive symptoms) and neurocognitive performances (e.g., VerbLearn and VisLearn) after rTMS treatment in patients.ConclusionThe low-frequency rTMS over the left TPJ area is an efficacious treatment for schizophrenia patients with AVH and could selectively modulate the neural basis underlying psychiatric symptoms and neurocognitive domains in schizophrenia.

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Section: Discussionsupporting

confidence: 92%

rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

et al. 2021

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“…In addition, the observed impairments in the understanding of paradoxical sarcasm correlated moderately with measures of psychopathology in the patients. This is consistent with some previous studies, although the literature regarding clinical correlates of social cognitive deficits in schizophrenia is mixed 2,[15][16][17][18] . Exploratory analyses (not corrected for multiple comparisons) revealed that the correlations with positive symptoms were driven by items covering delusions, hallucinatory behaviour, excitement, suspiciousness/persecution (strongest association) and hostility; Negative symptoms were due to associations with blunted affect, poor rapport and difficulty in abstract thinking (strongest association).…”

Section: Discussionsupporting

confidence: 92%

A nation-wide twin study of social cognition in schizophrenia spectrum disorders

2022

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We examined social cognition in 32 monozygotic (MZ) and 21 dizygotic (DZ) twin pairs concordant or discordant for a schizophrenia spectrum diagnosis and healthy control (HC) twin pairs (29 MZ/20 DZ). All participants were recruited through the Danish registers. Patients showed several deficits in the ability to detect sarcasm. Impairments were also observed in the unaffected MZ co-twins, indicating that social cognitive deficits could be a genetic vulnerability indicator of the disease. Worse social cognition was associated with lower intelligence and higher levels of psychopathology in patients.

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“…Schizophrenia patients have rigid eyes, are sensitive and suspicious, have unreasonable tension, fear, psychological changes, are easily irritable, have low self-care ability, are antisocial, etc. Severe schizophrenia may lead to suicide or other injuries [ 12] . Most studies [12] have shown that women, with high education levels, married, late onset, acute or subacute onset, cheerful personality before the disease, good interpersonal relations, and good social mechanisms and functions before the disease.…”

Section: Medications For Smd Patients In Fuzhoumentioning

confidence: 99%

“…Severe schizophrenia may lead to suicide or other injuries [ 12] . Most studies [12] have shown that women, with high education levels, married, late onset, acute or subacute onset, cheerful personality before the disease, good interpersonal relations, and good social mechanisms and functions before the disease.…”

Section: Medications For Smd Patients In Fuzhoumentioning

confidence: 99%

A Large Sample Epidemiological Survey of Severe Mental Disorders: Current Status and Prospects

Fuhao

Lin

Wei

et al. 2021

Preprint

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Objective: To investigate the prevalence, distribution characteristics, medication status, and management status of patients with severe mental disorders (SMD) in Fuzhou. The medication status and management status were compared between patients in urban and non-urban areas to provide scientific evidence for improving SMD prevention, control, and treatment in primary health care institutions. Methods: Data (case types, demographic data, distribution data, medication status, and management status, etc.) of 30,362 SMD patients in 12 districts, counties, and prefectures in the urban and non-urban areas of Fuzhou City were collected From March 2018 to September 2018. Three distributions were used to describe the epidemiological characteristics of SMD. Linear trend chi-square test was used to illustrate the relationship between the prevalence of SMD and monthly changes. χ2 test method was used to compare the severity in urban and non-urban areas (qualitative data of SMD patients). Results: A total of 30,362 registered SMD patients were identified in Fuzhou City (prevalence rate, 4.17‰), of which schizophrenia accounted for the highest number (26204, 86.31%), and paranoid psychosis had the least number (47, 0.15%). Moreover, most SMD patients were aged 18 (inclusive)-44 years old (45.38%). Most patients were farmers (30.23%), had a primary school and below education level (54.17%), were poor, with most below the poverty line standard (55.35%). The time-point prevalence of SMD was highest in Minqing County (5.29‰) and lowest in Mawei District (3.80‰). The prevalence rates of SMD were significantly different among various regions in Fuzhou (P<0.05). There was a linear trend between the month and SMD prevalence, with a statistically significant difference (P<0.05). A total of 22,989 (75.72%) of the patients were taking medications, and only 17,509 (57.67%) were taking medications regularly. Moreover, the rate of taking medications and regular-taking rates were higher in urban areas than in non-urban areas (P＜0.05). A total of 3065 patients were under management (10.09%). The management rate was higher in the urban areas than in the non-urban areas (P<0.05). Conclusion: Schizophrenia needs comprehensive prevention and control in Fuzhou. The management of severe mental disorders should focus on poor groups with low educational backgrounds. Drug usage and management are better in urban areas than in non-urban areas, and thus management should be enhanced in non-urban areas. The medication management and case management of patients with severe mental disorders in Fuzhou need further improvements.

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The difference of social cognitive and neurocognitive performance between patients with schizophrenia at different stages and influencing factors

Cited by 9 publications

References 48 publications

rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

A nation-wide twin study of social cognition in schizophrenia spectrum disorders

A Large Sample Epidemiological Survey of Severe Mental Disorders: Current Status and Prospects

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