The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection

Kittigul, Leera; Pitakarnjanakul, Piyamard; Sujirarat, Dusit; Siripanichgon, Kanokrat

doi:10.1016/j.jcv.2007.04.006

Cited by 131 publications

(112 citation statements)

References 15 publications

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“…15 Analysis of monthly dengue cases showed peak incidence in November 2006 ranging from October to December. This pattern is consistent with reports from other endemic countries [11][12][13] and correlates well with the hot summer and monsoon season, which provides ideal breeding conditions for Aedes aegypti.…”

Section: Discussionsupporting

confidence: 91%

“…12 This is contrary to other report which states that dengue mainly occurs in children less than 15 years of age. 13 It may represent the fact that dengue infection is asymptomatic in 80% of infants and children. The illness is more severe and begins more suddenly in adults.…”

Section: Discussionmentioning

confidence: 99%

“…7 The clinical features in our patients apart from high grade fever were vomiting, abdominal pain, body aches in about 55% of cases which is again comparable to documented clinical features. 3,9,12,13 Epistaxis, petechiae and gum bleeding were also noticed apart from the gastrointestinal bleeding. Maculopapular rash was found in 40 patients (34.5%).…”

Section: Discussionmentioning

confidence: 99%

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Dengue Virus Outbreak in the Year 2006 at a Tertiary Care Centre in Sindh

2008

j liaquat uni med health sci

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dengue Virus Outbreak in the Year 2006 at a Tertiary Care Centre in Sindh

2008

j liaquat uni med health sci

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“…1 With subsequent uncontrolled growth of cities, epidemics of Dengue fever associated with Dengue Hemorrhagic fever emerged as major public health problems. 2 Dengue virus is now the most common cause of arboviral diseases in the world. Dengue virus infection is increasingly being recognised as one of the world's major emerging infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia and raised hematocrit-predictor in dengue hemorrhagic fever

Upadhyay

Joshi

Upadhyay

2017

Int J Contemp Pediatr

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Background: This study evaluated the symptoms and routine laboratory investigation to arrive at a bedside diagnosis of dengue hemorrhagic fever and to predict the prognosis on the basis of clinical features and investigation.Methods: This was a prospective study and included children age up to 15 years admitted in the pediatric ward over 2 years period. Dengue fever and dengue hemorrhagic fever were defined according to WHO guidelines.Results: Out of 90 Dengue positive children 44 (48.8%) were of Dengue Hemorrhagic Fever. The common clinical features were fever (100%), bleeding (100%), and rash (84%). 100% children had thrombocytopenia and 36% had raised hematocrit.Conclusions: Triad of fever, bleeding tendencies and rash along with thrombocytopenia and raised hematocrit can be considered as predictive marker for the early diagnosis of dengue hemorrhagic Fever before the specific test like NS1 antigen and antibodies are available.

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“…There are three main laboratory methods to diagnose dengue infection: viral isolation in culture, detection of viral RNA, NS1 antigen and specific IgM/IgG antibodies in paired sera. The gold standard is usually a combination of these methods 8 . However, methods such as virus isolation and genomic RNA detection (PCR), need a specialized laboratory, well trained laboratory personnel and costly, which are not widely available in resource limited settings.…”

Section: Introductionmentioning

confidence: 99%