Thrombocytopenia and raised hematocrit-predictor in dengue hemorrhagic fever

Upadhyay, Nisha; Joshi, Himanshu; Upadhyay, Chintan

doi:10.18203/2349-3291.ijcp20172626

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…High hematocrit points towards plasma leakage from blood capillaries. Our study demonstrated greater than 45 hematocrit in all age groups which is in alignment with other study (21). Hematocrit values are quite helpful in monitoring amount of intravenous fluid and also direct us about the use of blood products if needed in dengue patients.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Khan¹,

Sajjad²,

Mansoori³

et al. 2023

LMRJ

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Dengue virus belongs to flavivirus family which gains entry into the host organism through skin following an infected mosquito bite. Humoral, cellular, and innate host immune responses are involved in the progression of the disease. Dengue fever is getting common in Pakistan, and at times shows high mortality, but there is limited literature available. Therefore, this study was designed to evaluate hematological parameters in patients with dengue fever. This was a retrospective cross-sectional study conducted in the Department of Microbiology, Dow Diagnostic Reference and Research Laboratory, Karachi, Pakistan from 1 January 2021 till December 2021. A total of 6140 were collected, out of which 1746 were found positive. Dengue infection was confirmed by rapid screening NS1 antigen by ICT method. IgM antibodies were detected by Enzyme linked immunosorbent assay (ELISA). Hematological analysis was performed on Sysmex analyzer. Among the 1746 positive samples, 1036 (60%) were males and 710 (40%) were females. More than 10 hemoglobin and 45 hematocrits were found in greater than 40% of cases. Leucopenia less than 4000 was observed mostly in age group 0-20 years. Eosinophilia, basophilia, lymphocytosis and atypical lymphocytosis were shown equally in all age groups. Our study found greater incidence of Dengue fever among 21-40 years of age group with male predominance. Hematological spectrum revealed thrombocytopenia, lymphocytosis, high hematocrit, eosinophilia, basophilia and monocytosis at the time of diagnosis.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Khan¹,

Sajjad²,

Mansoori³

et al. 2023

LMRJ

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“…Thrombocytopenia and increments in the hematocrit percentage in DENV-infected patients are considered warning signs by the WHO and correlate with viremia and severity of the clinical presentation of dengue ( WHO, 2009 ; Upadhyay et al., 2017 ; Pathak et al., 2021 ). We observed a correlation of DENV isolates susceptibility to type I interferon antiviral response with the increment of hematocrit percentage and thrombocytopenia ( Figure 5 ), supporting the hypothesis that type I interferon susceptibility of DENV could be a driving factor in the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Castro-Jiménez

Gómez-Legorreta

López-Campa

et al. 2022

Front. Cell. Infect. Microbiol.

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Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence. To evaluate if Flavivirus variants with different phenotypes cocirculate during outbreaks, we isolated dengue and Zika viruses from blood samples of febrile patients from Oaxaca City during the 2016 and 2019 epidemic years. We compared their replication kinetics in human cells, susceptibility to type I interferon antiviral response, and the accumulation of subgenomic RNA on infected cells. We observed correlations between type I interferon susceptibility and subgenomic RNA accumulation, with high hematocrit percentage and thrombocytopenia. Our results suggest that Flaviviruses that cocirculate in Oaxaca, Mexico, have variable sensitivity to the antiviral activity of type I interferons, and this phenotypic trait correlates with the severity of the disease.

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“…Increased hematocrit value was found in 88(47%) cases of our dengue children, which was 36% in Upadhya N et al study. 15 Serial hematocrit values may help in increasing or decreasing intravenous fluids and guides us whether blood or blood products are needed or not.A significant number of thrombocytopenic children developed raised hematocrit (Table IV). This finding was consistent with the study of Jayashree K et al 4 Raised hematocrit along with moderate to severe thrombocytopenia was found significant in the development of severe dengueinfection (Table V).…”

Section: Methodsmentioning

confidence: 99%

Importance of Platelet Count and Hematocrit in Dengue Fever in Children

Rahat

Khanam

Iman

et al. 2021

Bangladesh J Child Health

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Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

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Thrombocytopenia and raised hematocrit-predictor in dengue hemorrhagic fever

Cited by 4 publications

References 3 publications

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Evaluation of Spectrum of Laboratory Hematological Manifestations in Dengue Fever

Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Importance of Platelet Count and Hematocrit in Dengue Fever in Children

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