The different effects of Helicobacter pylori strains on basal and histamine-stimulated acid and pepsin production: An in vitro study

Ben-Hamida, A.; Man, W. K.; Elgaddal, A. A.; Karim, Q. N.; Spencer, J. R.

doi:10.1007/s000110050269

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2002

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“…Moreover, secretion was inhibited with both lanthanum and W-7. Other authors 23 have reported that H pylori sonicates significantly increased basal and histamine stimulated pepsinogen secretion from human chief glands. However, Cave and Cave 11 found an additive effect with carbachol and CCK-OP.…”

Section: Discussionmentioning

confidence: 85%

Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells

Lorente

Doiz²,

Serrano³

et al. 2002

Gut

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Background: Different acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori induced gastric mucosal damage are not completely understood. Aim: To determine the effects of H pylori on pepsinogen secretion from isolated human peptic cells. Methods: Dispersed human peptic cells were prepared from endoscopically obtained biopsy specimens after collagenase digestion, mechanical disruption, and density gradient centrifugation. H pylori was obtained from gastric biopsies (antrum and body), and cultured in non-selective and selective media. Isolates of H pylori were used at different concentrations (1-20×10 6 colony forming units (cfu)).Results: H pylori (10

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Section: Discussionmentioning

confidence: 85%