The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Pak, Kyung Ho; Jo, Ala; Choi, Heekyung; Choi, Yu-Sung; Kim, Hyun Ki; Cheong, Jae‐Ho

doi:10.1186/s12885-015-1501-9

Cited by 24 publications

(26 citation statements)

References 41 publications

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“…Our results are consistent with accumulated lines of evidence that strongly suggest the role of tumour-induced lymphangiogenesis in progression and metastasis of various cancers, i.e. prostate adenocarcinoma, oesophageal squamous cell carcinoma, gastric, breast and lung cancer (28)(29)(30)(31)(32). Considering haematological malignancies, positive correlation between increased number of PDPN-positive vessels and disease progression was reported in Sézary syndrome, the most common, aggressive CTCL (33).…”

Section: Discussionsupporting

confidence: 91%

Podoplanin Expression Correlates with Disease Progression in Mycosis Fungoides

Jankowska‐Konsur

Kobierzycki²,

Grzegrzółka³

et al. 2017

Acta Derm Venerol

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The aim of this study was to investigate the role of lymphangiogenesis in the clinical progression and outcome of mycosis fungoides. Immunohistochemistry and Western blot techniques were used to assess the expression of podoplanin and vascular endothelial growth factor C in mycosis fungoides. Expression of vascular endothelial growth factor C measured by immunohistochemistry was significantly higher in mycosis fungoides samples in comparison with control cases (chronic benign dermatoses) (p = 0.0012). Increased expression of podoplanin was found in advanced vs. early mycosis fungoides (p < 0.0001), and was positively correlated with cutaneous and nodal involvement (p < 0.001, p < 0.0001; respectively). Higher podoplanin expression was also significantly associated with shorter survival (p < 0.001). Strong positive correlation was observed between expression of podoplanin analysed by immunohistochemistry and Western blot (r = 0.75, p < 0.0001). A similar association was shown regarding expression of vascular endothelial growth factor C (r = 0.68, p = 0.0007). In conclusion, these results suggest that increased expression of podoplanin is associated with poor clinical course, as well as shorter survival, of patients with mycosis fungoides.

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Section: Discussionsupporting

confidence: 91%

Podoplanin Expression Correlates with Disease Progression in Mycosis Fungoides

Jankowska‐Konsur

Kobierzycki²,

Grzegrzółka³

et al. 2017

Acta Derm Venerol

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“…Watanabe et al reported that intranodal lymphatic vessel density was significantly correlated with the size of the metastasis [27]. Furthermore, peritumoral lymphovascular density was significantly increased in cases with lymph node metastasis [28]. These results suggest that the lymphatic network develops both morphologically and immunologically in cases with lymph node metastasis.…”

Section: Discussionmentioning

confidence: 92%

Auxiliary diagnosis of lymph node metastasis in early gastric cancer using quantitative evaluation of sentinel node radioactivity

et al. 2015

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Background Sentinel node (SN) mapping using dye and radioisotope (RI) tracer has been reported to be feasible in cases of early gastric cancer. Because accurate diagnosis of micrometastasis is sometimes difficult in the limited time available during surgery, a faster and simpler method of improving the intraoperative diagnostic precision of lymph node metastasis is needed. The amount of tracer deposited in an SN can be determined from its radioactivity; however, the significance of the RI count has not been fully discussed. We investigated the clinical impact of the RI count when used as an adjunct to conventional lymph node dissection when diagnosing lymphatic metastasis in cases of early gastric cancer. Methods From 2008 to 2009, patients with clinically diagnosed T1N0M0 gastric cancers who underwent gastrectomy and SN mapping were enrolled. SNs were examined by intraoperative and postoperative pathology. The RI count was measured for each SN with a handheld gamma probe; the correlation between nodal metastasis and the RI count was assessed. Results A total of 308 SNs were harvested from 72 patients. Patients with SN metastasis had significantly higher total RI counts than those without SN metastasis (p = 0.007). Among cases with SN metastasis, RI counts were also significantly elevated in metastasis-positive nodes, stations, and basins. In these cases, the most of SNs having the highest RI count in each case had metastasis including isolated tumor cells. Conclusion In early gastric cancer patients, a high RI count from an SN was correlated with lymph node metastasis. Therefore, RI counting may aid efficient pathological diagnosis and focused lymph node dissection.

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“…Several studies have associated I-LVD with tumor LN metastasis in head and neck squamous cell carcinoma [55,56], papillary thyroid carcinoma [58], pancreatic endocrine tumors [57], and gastric carcinoma [58].…”

Section: Discussionmentioning

confidence: 99%

Expression of D2-40 in Benign and Malignant Breast Lesions and Study the Correlation between Lymphovascular Density and other Prognostic Factors of Breast Cancer

Abdel-Dayem¹,

Ibraheim²

2017

Arch Can Res

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Background: D2-40 is a mouse monoclonal antibody specific for human podoplanin and has been used in identifying lymphovascular invasion (LVI) of tumors; also its expression has been used as a marker for myoepithelial cells (MEC) of breast. Lymphangiogenesis, assessed as lymphovascular density (LVD), is the initial step of generalized tumor lymphovascular invasion (LVI). It also involves VEGF-C as the most important protein family. Lymphangiogenesis among breast cancer cases correlations with several clinicopathological factors are important to determine prognosis and treatment strategies, but results have been controversial and require clarification.

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The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Cited by 24 publications

References 41 publications

Podoplanin Expression Correlates with Disease Progression in Mycosis Fungoides

Podoplanin Expression Correlates with Disease Progression in Mycosis Fungoides

Auxiliary diagnosis of lymph node metastasis in early gastric cancer using quantitative evaluation of sentinel node radioactivity

Expression of D2-40 in Benign and Malignant Breast Lesions and Study the Correlation between Lymphovascular Density and other Prognostic Factors of Breast Cancer

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