The differential role of the dorsal hippocampus in initiating and terminating timed responses: A lesion study using the switch-timing task

Gupta, Tanya A.; Daniels, Carter W.; Ortiz, J. Bryce; Stephens, McAllister; Overby, Paula F.; Romero, Korinna; Conrad, Cheryl D.; Sanabria, Federico

doi:10.1016/j.bbr.2019.112184

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…However, converging evidence suggests that the hippocampus is only recruited at baseline when exceptionally long intervals are used-on the order of several minutes. Specifically, when rodents time multi-second intervals, such as the ones used here, hippocampal effects are often absent or minor (Dietrich et al, 1997;Dietrich & Allen, 1998;Gupta et al, 2019;Jacobs et al, 2013). However, when rodents track intervals lasting several minutes, hippocampal manipulations begin to exert an effect (Jacobs et al, 2013;Shikano et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

The dorsal hippocampus’ role in context-based timing in rodents

Corte

Farley

Heslin

et al. 2022

Neurobiology of Learning and Memory

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Section: Discussionmentioning

confidence: 99%

The dorsal hippocampus’ role in context-based timing in rodents

Corte

Farley

Heslin

et al. 2022

Neurobiology of Learning and Memory

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“…Consistent with single FI schedules, switch-timing may be conceived of as entraining the same behavioral modes (signified by "circles containing underlined text"), but with a slight modification: after failing to find food at the Short-FI in Long-FI trials, subjects transition back to general search before returning to pre-food focal search (signified by the "bidirectional arrow connecting pre-food focal search on the Short FI with general search on the Long FI"). This configuration is supported by the observation that there is typically a 2-s or longer difference between LTDs and LTSs, indicating that subjects are pausing (see Gupta et al 2019;Maggi et al 2014, Tosun, Gür, & Balci, 2016. Such a pause may be indicative of subjects transitioning back to general search before returning to pre-food focal search at the Long-FI (Killeen, Hall, Reilly, & Kettle 2002;Sanabria et al 2019), rather than a continuation and spatial relocation of pre-food focal search, which would predict shorter transitions 1 .…”

Section: Introductionmentioning

confidence: 85%

“…Switch-timing training appears to be critical for determining whether inferences about interval timing may be drawn from the distribution of LTDs. Indeed, similar difficulties in interpreting effects on LTDs have been observed elsewhere (e.g.,Gupta et al, 2019). In contrast, the sensitivity of LTSs to various manipulations appears to depend less on training (LTS effects in Experiments 1 and 2 were replicated).…”

mentioning

confidence: 84%

Interval Timing and Motivation are Dissociable when Interval-Initiating Responses are Discriminable from Target Responses

Cw¹,

Sanabria²

2019

Preprint

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Data have accumulated suggesting that motivation and timing are correlated processes, yet few studies have tested whether motivation and timing are procedurally dissociable. This may be attributed to the fact that the most common framework in which to study timing, the pacemaker-accumulator model, does not readily suggest a route by which to dissociate motivation and timing. In contrast, the behavioral systems framework suggests that motivation and timing could be dissociated if subjects were trained in response-initiated (RI) interval-timing procedures rather than in common externally-initiated (EI) procedures. RI procedures were predicted to enhance temporal control and yield timing performance robust to fluctuations in motivation. Experiment 1 tested this hypothesis by training rats to either initiate switch-timing trials with a single press on the lever associated with the shorter FI schedule (SL-RI), or wait for switch-timing trials to be initiated (EI). Motivation was varied through pre-feeding. SL-RI and EI rats showed similar levels of temporal control and sensitivity to pre-feeding in their switch-timing performance. Experiment 2 tested a revised RI hypothesis, the discriminative-RI hypothesis, which predicts that as the trial-initiating response becomes progressively different from target responses, motivation and timing are increasingly dissociated. This experiment replicated Experiment 1 and added a trial-initiating condition in which a nose-poke into a nose port (NP-RI) initiated trials. As predicted, the sensitivity of switching-timing performance to pre-feeding scaled such that EI > SL-RI > NP-RI. These data suggest that it is possible to dissociate timing and motivation, challenging the notion that these processes are correlated.

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Internal-Clock Models and Misguided Views of Mechanistic Explanations: A Reply to Eckard & Lattal (2020)

Sanabria

2020

Perspect Behav Sci

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The differential role of the dorsal hippocampus in initiating and terminating timed responses: A lesion study using the switch-timing task

Cited by 5 publications

References 33 publications

The dorsal hippocampus’ role in context-based timing in rodents

The dorsal hippocampus’ role in context-based timing in rodents

Interval Timing and Motivation are Dissociable when Interval-Initiating Responses are Discriminable from Target Responses

Internal-Clock Models and Misguided Views of Mechanistic Explanations: A Reply to Eckard & Lattal (2020)

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