2022
DOI: 10.3390/biomedicines10092226
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The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials

Abstract: Current research across the globe still focuses strongly on naturally derived biomaterials in various fields, particularly wound care. There is a need for more effective therapies that will address the physiological deficiencies underlying chronic wound treatment. The use of moist bioactive scaffolds has significantly increased healing rates compared to local and traditional treatments. However, failure to heal or prolonging the wound healing process results in increased financial and social stress imposed on … Show more

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Cited by 18 publications
(12 citation statements)
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“…As shown in Figure 4 , the XRD pattern reveals a distinct broad diffraction peak located at 2 θ = 24.01°, corresponding to interlayer spacing in graphite (0.34 nm) [ 15 ]. This finding indicates the amorphous carbon phase of BCDs nano-biocarrier without any crystalline phases and could attribute to the introduction of more oxygen-containing groups [ 1 , 45 ]. Furthermore, the results confirm that the BCDs nano-biocarrier exhibit graphitic nature with highly disordered carbon atoms, hence containing graphite-like structures [ 14 , 46 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…As shown in Figure 4 , the XRD pattern reveals a distinct broad diffraction peak located at 2 θ = 24.01°, corresponding to interlayer spacing in graphite (0.34 nm) [ 15 ]. This finding indicates the amorphous carbon phase of BCDs nano-biocarrier without any crystalline phases and could attribute to the introduction of more oxygen-containing groups [ 1 , 45 ]. Furthermore, the results confirm that the BCDs nano-biocarrier exhibit graphitic nature with highly disordered carbon atoms, hence containing graphite-like structures [ 14 , 46 ].…”
Section: Resultsmentioning
confidence: 99%
“…The total global number of skin injury cases has substantial healthcare ramifications, as it represents almost 50% of the world’s yearly expenditure in the aspect of healthcare [ 1 ]. Understandably, wound healing is well-known to be one of the most critical challenges in medical society [ 2 ].…”
Section: Introductionmentioning
confidence: 99%
“…The presence of nanofibrous networks, nanoparticles and micro-pores significantly influences interactions between NEUs and macrophages, angiogenesis and overall tissue regeneration [ 141 ]. Naturally derived polymers, which resemble the fibrous ECM, hold great promise in maintaining material functionality and fostering positive inflammatory responses [ 142 ]. These responses ultimately lead to tissue regeneration without fibrosis.…”
Section: Modulating Innate Immunity In the New Generation Of Wound-he...mentioning
confidence: 99%
“…Skin injuries can have a significant impact on an individual's overall health and well-being, particularly when it comes to full-thickness, acute, and chronic wounds. 1 A complex series of interactions between various cell types, cytokine mediators, and the extracellular matrix necessitate appropriate treatments for successful wound healing. 2 Therefore, the development of well-designed dressings that act as protective coatings, while promoting rapid wound closure and accelerated healing and causing minimal scarring, is important for healthcare systems.…”
Section: Introductionmentioning
confidence: 99%