The Dispensatory of the United States of America. Ed. 23

Wood, Horatio C.; Youngken, Heber W.; Gershenfeld, Louis

doi:10.1097/00005053-194505000-00046

Cited by 4 publications

(24 citation statements)

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“…The juice from the leaves is "cathartic, acting on large intestine; vermifuge, emmenagogue." Wood (1926) The plant is cathartic.…”

Section: Al ( 1988)mentioning

confidence: 99%

“…Schauemburg and Paris ( 1977) The plant is antispasmodic, carminative, stomachic, and tonic .. Wood (1926) The plant is "used as an aromatic in flatulent colic," as a "domestic diaphoretic and diuretic," and "externally as a counterirritant." Uphof (1968, p.37) "Decoction of root is used as a tea for bronchial colds and indigestion.…”

Section: Collected From Hierberia San Martin Caballero (#177)mentioning

confidence: 99%

“…Sarkis ( 1985) The infusion is used for arteriosclerosis. Wood (1926) The leaves are used for diarrhea and as an anthelmintic. Hierberia Divina Providencia --An infusion of the fruit is used for kidney problems and the dissolution of kidney stones.…”

Section: Martinez ( 1969}mentioning

confidence: 99%

“…Uphof (1968, p. 111) "Dried fruit used medicinally as purgative, laxative, for habitual constipation." Wood (1926) "Cassia pulp is laxative, and may be advantageously given in small doses in cases of habitual costiveness.…”

Section: Casimiroa Edulismentioning

confidence: 99%

“…In the treatment of amoebic dysentery it has been found that a f luidacetextract in the proportion of one part in a million is sufficient to render Entamoeba histolytica immobile." Wood (1926) Hierberia Cortez --An infusion of the whole plant is employed as an antidysenteric and vermifuge.…”

Section: Casimiroa Edulismentioning

confidence: 99%

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The market medicinal plants of Monterrey, Nuevo León, México

Nicholson

Arzeni

1993

Econ Bot

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“…The juice from the leaves is "cathartic, acting on large intestine; vermifuge, emmenagogue." Wood (1926) The plant is cathartic.…”

Section: Al ( 1988)mentioning

confidence: 99%

Section: Collected From Hierberia San Martin Caballero (#177)mentioning

confidence: 99%

Section: Martinez ( 1969}mentioning

confidence: 99%

Section: Casimiroa Edulismentioning

confidence: 99%

Section: Casimiroa Edulismentioning

confidence: 99%

See 3 more Smart Citations

The market medicinal plants of Monterrey, Nuevo León, México

Nicholson

Arzeni

1993

Econ Bot

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Antibacterial Activitv of the Heartwood of Haematoxylon braziletto**University of California, School of Pharmacy, San Francisco 22

Pratt

Yuzuriha

1959

Journal of the American Pharmaceutical Association (Scientific

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Putnam, Merritt, and the Discovery of Dilantin®

Friedlander

1986

Epilepsia

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In the first part of this essay, the "common wisdom" about Putnam and Merritt's contributions to the treatment of epilepsy was summarized (Rowland, 1982). Based on the history that has been presented here, how true are these "wisdoms"? Putnam and Merritt did devise "a simple and reliable method to test drugs of anticonvulsant effect" and they did show "that anticonvulsant effects in cats accurately predicted effects in humans," but others before them had done these same things. Dilantin, contrary to common wisdom, was not the first anticonvulsant drug to be tested in animals before it was given to human subjects; at least a year before, Cobb and his co-workers had done the same thing using vital dyes. However, Dilantin did represent the first time an anticonvulsant tested in animals was subsequently studied in a large series of patients. Nor were Putnam and Merritt the first to show that "anticonvulsant and sedative effects of drugs could be separated." Potassium borotartrate, ketogenic diet, ketone bodies, and vital dyes were anticonvulsive without necessarily being sedative. However, Putnam and Merritt were probably the first to make so explicit a statement to this effect. It may well have been this particular statement--and the fact that it was so well heard by other researchers--that represented their greatest achievement. In Kuhn's theory of scientific revolutions, the great step forward may not be so much the accumulation of evidence that the existing paradigm is not a feasible one, but rather the use of this evidence to form a new model or paradigm which is then accepted by normal science in such a fashion that the results prove to be productive. This, it would seem, is what Putnam and Merritt did. From it came their own major discovery, Dilantin, which, in Rowland's words, remains "a mainstay of treatment" for epilepsy up to the present time, and which "opened the way to the development of other anticonvulsant drugs."

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The Dispensatory of the United States of America. Ed. 23

Cited by 4 publications

References 0 publications

The market medicinal plants of Monterrey, Nuevo León, México

The market medicinal plants of Monterrey, Nuevo León, México

Antibacterial Activitv of the Heartwood of Haematoxylon braziletto**University of California, School of Pharmacy, San Francisco 22

Putnam, Merritt, and the Discovery of Dilantin®

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