THE DISTRIBUTION AND FATE OF d-TUBOCURARINE

Distribution and pharmacokinetics of14C-toxiferine in rats

“…The distribution of toxiferine is as one would expect for a highly watersoluble substance and it compares essentially with that of other nondepolarizing curare alkaloids (1,5). The skeletal muscle takes up little toxiferine, which is mostly concentrated in the endplates as a u t o r a d i o g r a p h i c investigations have demonstrated [7].…”

“…Non-depolarizing curare alkaloids are metabolized only to a minimal extent in the organism [1,2,5,8,9]. Differences in duration of the effect of these alkaloids result from variations in distribution, binding and elimination.…”

Comparative distribution of two antidepressant drugs (imipramine and indalpine) in the rat as determined by analog computer simulation

“…It was found that during the process of simulation an acceptor tissue depot had to be included to explain the data as had been previously suggested by Cavillito (8) or Cohen et al (9). Moreover, the transfer of the drugs from the intestinal tract to the blood (KSl) was negligible.…”

Adjudicating pathological criminal incapacity within a climate of ultimate issue barriers: A comparative perspective

“…110 • Federal Rule 704(b) admits the most confusing expert testimony, the mental health expert's diagnosis, whilst excluding the least confusing testimony, the expert's opinion as to the mental state or sanity of the defendant. 111 It is clear that there is much controversy surrounding Federal Rule 704(b). Although penultimately framed in statutory form, this rule is unworkable and problematic as it leads to unnecessary complications in the application of the insanity defence.…”