The distribution in mice of intravenously administered labelled<i>Candida albicans</i>

Trnovec, T.; Šikl, D.; Zemánek, M.; Faberová, V.; Bezek, S; Gajdosík, A; Koprda, V.

doi:10.1080/00362177885380411

Cited by 11 publications

(6 citation statements)

References 4 publications

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“…Cumulation of yeasts in the liver by means of radioactively labelled cells of C. albicans was also observed by Trnovec et a!. [35]. The histopathological findings of the present authors in the organs of infected mice are very similar to the findings reported by other authors [16,19,36], furthermore they are nearly identical with the histopathological findings in the kidneys of patients with acute leukaemia, whose disease had been complicated by systemic trichosporosis [11 ].…”

Section: Discussionsupporting

confidence: 91%

Pathogenicity of Trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice

Pospíšil¹,

Postupa²,

Otčenášek³

et al. 1990

Mycoses

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The authors describe the course of experimental trichosporosis in normal and X-irradiated ICR mice after i.v. inoculation with Trichosporon capitatum. The irradiated animals were considerably more sensitive to infection than normal animals. The LD50 challenge dose used was by approximately two orders lower (1 X 10(3) c.f.u. ml-1) in irradiated mice than in control animals. The histopathological examination of the internal organs of the infected mice demonstrated that the greatest tissue damage was associated with the kidneys, liver and spleen. However, the infectious agent was also found in heart, lungs and brain. The degree of impairment of the tissues was dependent on the inoculation dose and on the irradiation status. Miconazole (50 mg kg-1) was administered i.p. immediately after inoculation with Ts. capitatum and resulted in an alteration of infection and prolonged survival time. Miconazole was ineffective when challenge dose were used which produced 100% mortality (1 X 10(6) and 1 X 10(4) c.f.u. ml-1 for normal and irradiated mice, respectively). With the use of these doses also the course of infection was nearly identical both in the miconazole-treated and untreated animals.

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Section: Discussionsupporting

confidence: 91%

Pathogenicity of Trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice

Pospíšil¹,

Postupa²,

Otčenášek³

et al. 1990

Mycoses

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“…counts, if compared to the other organs. These data agree with reports in the literature, which emphasize the efficiency of this organ to retain and eliminate viable structures of both Candida morphology (blastospores and pseudohypha) in models of experimental infection in vivo (5,6,18). In the present study, a correlation between the variation of c.f.u counts over the period of infection and pneumonitis was not observed.…”

Section: Discussionsupporting

confidence: 79%

“…The literature mentions that yeasts are generally recovered from the blood only after a few hours of inoculation. This fact corroborates with the hypothesis of the efficiency of the parenchymatous organs to quickly remove C. albicans cells from the bloodstream (6,17,18).…”

Section: Discussionsupporting

confidence: 78%

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Model of experimental infection in healthy and immunosuppressed swiss albino mice (Mus musculus) using Candida albicans strains with different patterns of enzymatic activity

Chaves¹,

Cavalcanti²,

Carneiro-Leão³

et al. 2004

Braz. J. Microbiol.

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With the purpose to evaluate Candida albicans virulence in vivo, two strains selected were based on their phospholipase and proteinase activity, and used in a model of experimental infection. One strain, isolated from vaginal secretion, was stocked at the URM Culture Collection for 43 years and presented high phospholipase (Pz=0.217) and proteinase (1.386 U.mL -1 ) activity. The other strain was a fresh strain isolated from oropharyngeal secretion of an AIDS patient, and presented low phospholipase (Pz=0.482) and proteinase (0.780 U.mL -1 ) activity. The strains were inoculated via intraperitoneum in immunosuppressed and non-immunosuppressed mice (Mus musculus) and the infection was evaluated over a period of 21 days. Liver, spleen, lungs and kidneys were aseptically removed and the blood of the animals was collected every 72 h. The number of colony forming units (c.f.u) isolated from each organ was counted and a histopathologic examination was performed. The freshly isolated strain was more virulent than the stocked strain, as shown by the number of positive cultures and severity of the lesions observed at the histopathologic examination. A correlation between the in vitro enzymatic activity and the in vivo virulence was not observed.

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“…Trnovec et aL [34] and Iannini et al [19] studied the distribution in mice of intravenously administered radiolabeled cells of Candida albicans and obtained useful information about various parameters important in host defense against Candida infection. A similar study has not heretofore been done with C. neoformans.…”

mentioning

confidence: 99%

Effects of diethylstilbestrol and cyclophosphamide on the pathogenesis of experimentalCryptococcus neoformansinfections

Duke¹,

Fromtling²

1984

Med Mycol

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The distribution in mice of intravenously administered labelledCandida albicans

Cited by 11 publications

References 4 publications

Pathogenicity of Trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice

Pathogenicity of Trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice

Model of experimental infection in healthy and immunosuppressed swiss albino mice (Mus musculus) using Candida albicans strains with different patterns of enzymatic activity

Effects of diethylstilbestrol and cyclophosphamide on the pathogenesis of experimentalCryptococcus neoformansinfections

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