The distribution of fluoride of prenatal origin in the rat—A pilot study

Biochemical and Histopathological Effects of Chronic Fluorosis on Lung Tissues of First Generation Rats

“…Free radicals effect important cellular components such as lipids, proteins, DNA and carbohydrates. They have a great affinity to macromolecules such as phospholipids, glycolipids, unsaturated lipid acids of glycerides and membrane proteins (5,7). In addition, several cell functions or components such as enzyme activities, receptors, transmitters, ion channels and permeability could be affected.…”

The cariostatic mechanisms of fluoride

“…Many clinical trials were designed to prove the systemic mode of action (2)(3)(4). Additionally, laboratory analyses revealed that fluoride concentration in surface enamel was higher in teeth that developed under the influence of water fluoridation (5). A hypothesis evolved which suggested that fluoride helped to make the enamel crystal "more perfect", and therefore less acid soluble.…”

Systemic versus Topical Fluoride

“…It could be demonstrated that the prevalence of overt carious lesions in the permanent as well as in the primary dentition was lower in residents from areas with fluoridated drinking water compared to those living in non-fluoridated areas [Backer Dirks et al, 1978;Thylstrup et al, 1982;Newbrun, 1989;Ripa, 1993]. Additionally, laboratory analyses revealed that fluoride concentration in surface enamel was higher in teeth that developed under the influence of water fluoridation [Chan et al, 1989;Takeuchi et al, 1996]. It was also found that the prenatal administration of fluoride supplements could reduce caries prevalence in deciduous teeth [Glenn et al, 1982].…”