Abstract:For non‐Mendelian diseases, the distribution of shared haplotypes in multiplex sibships provides a powerful tool to investigate the hypothesis that disease susceptibility genes map in the neighborhood of the HLA complex. Occasionally, ambiguous sibships arise because all offspring inherit an HLA haplotype that is identical in state from an untyped parent. The scoring procedure developed here uses the population frequency of the haplotype as well as the sibship size to estimate the probability that, with respec… Show more
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